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- W1508842216 abstract "The visual pigment, rhodopsin, is localized in the retinal rod outer segment (ROS) disk membrane and is a prototypical member of the seven transmembrane helical, superfamily of G protein-coupled receptors. Photoactivation of rhodopsin results in the formation of an active conformation R* that binds the rod cell G protein, (transducin (Gt), and activates it by catalyzing the exchange of Gt-bound GDP for GTP. A single R* can activate several hundred G t molecules during its lifetime. The alpha subunit of Gt, Gtα, activates the effector enzyme, a cGMP phosphodiesterase (PDE), by binding its inhibitor subunit, thus initiating cGMP hydrolysis. The reduction in cGMP concentration results in a hyperpolarization of the ROS plasma membrane, because of the reduced flux of Na+ ions through the cGMP-gated channels, with concomitant change in neurotransmitter release at the synaptic end of the rod cell, which generates the neuronal response to light." @default.
- W1508842216 created "2016-06-24" @default.
- W1508842216 creator A5032181672 @default.
- W1508842216 creator A5082333968 @default.
- W1508842216 date "1996-01-01" @default.
- W1508842216 modified "2023-10-15" @default.
- W1508842216 title "Rhodopsin structure and function" @default.
- W1508842216 cites W101220866 @default.
- W1508842216 cites W119946315 @default.
- W1508842216 cites W1445935732 @default.
- W1508842216 cites W1491721575 @default.
- W1508842216 cites W1514240524 @default.
- W1508842216 cites W1514276081 @default.
- W1508842216 cites W1524291039 @default.
- W1508842216 cites W1558921401 @default.
- W1508842216 cites W1566199310 @default.
- W1508842216 cites W1584684122 @default.
- W1508842216 cites W1590595627 @default.
- W1508842216 cites W1594236032 @default.
- W1508842216 cites W1601047299 @default.
- W1508842216 cites W1653393467 @default.
- W1508842216 cites W1970028705 @default.
- W1508842216 cites W1970726096 @default.
- W1508842216 cites W1973665843 @default.
- W1508842216 cites W1974233292 @default.
- W1508842216 cites W1975297546 @default.
- W1508842216 cites W1976351696 @default.
- W1508842216 cites W1977062927 @default.
- W1508842216 cites W1979643377 @default.
- W1508842216 cites W1979946495 @default.
- W1508842216 cites W1980568851 @default.
- W1508842216 cites W1981334683 @default.
- W1508842216 cites W1983069070 @default.
- W1508842216 cites W1987877180 @default.
- W1508842216 cites W1989171306 @default.
- W1508842216 cites W1990718436 @default.
- W1508842216 cites W1991655565 @default.
- W1508842216 cites W1992004763 @default.
- W1508842216 cites W1993343824 @default.
- W1508842216 cites W1993620919 @default.
- W1508842216 cites W1993799801 @default.
- W1508842216 cites W1994215475 @default.
- W1508842216 cites W1994897010 @default.
- W1508842216 cites W1995295460 @default.
- W1508842216 cites W1998195984 @default.
- W1508842216 cites W1998360931 @default.
- W1508842216 cites W2000064253 @default.
- W1508842216 cites W2001848431 @default.
- W1508842216 cites W2002523841 @default.
- W1508842216 cites W2003507857 @default.
- W1508842216 cites W2005322830 @default.
- W1508842216 cites W2006296579 @default.
- W1508842216 cites W2007195248 @default.
- W1508842216 cites W2008874451 @default.
- W1508842216 cites W2009415098 @default.
- W1508842216 cites W2009514412 @default.
- W1508842216 cites W2010358621 @default.
- W1508842216 cites W2010905180 @default.
- W1508842216 cites W2011774157 @default.
- W1508842216 cites W2012638283 @default.
- W1508842216 cites W2013836165 @default.
- W1508842216 cites W2016537683 @default.
- W1508842216 cites W2017218609 @default.
- W1508842216 cites W2017344454 @default.
- W1508842216 cites W2017754384 @default.
- W1508842216 cites W2019916575 @default.
- W1508842216 cites W2020612204 @default.
- W1508842216 cites W2020628471 @default.
- W1508842216 cites W2020792265 @default.
- W1508842216 cites W2023428879 @default.
- W1508842216 cites W2023619128 @default.
- W1508842216 cites W2027997279 @default.
- W1508842216 cites W2028331751 @default.
- W1508842216 cites W2029087881 @default.
- W1508842216 cites W2031082470 @default.
- W1508842216 cites W2032765781 @default.
- W1508842216 cites W2033241060 @default.
- W1508842216 cites W2035516048 @default.
- W1508842216 cites W2036330162 @default.
- W1508842216 cites W2037664056 @default.
- W1508842216 cites W2038736781 @default.
- W1508842216 cites W2039884855 @default.
- W1508842216 cites W2040239540 @default.
- W1508842216 cites W2042171246 @default.
- W1508842216 cites W2043439684 @default.
- W1508842216 cites W2043774431 @default.
- W1508842216 cites W2044398898 @default.
- W1508842216 cites W2047222957 @default.
- W1508842216 cites W2048971266 @default.
- W1508842216 cites W2049609999 @default.
- W1508842216 cites W2051401374 @default.
- W1508842216 cites W2053015438 @default.
- W1508842216 cites W2053681539 @default.
- W1508842216 cites W2054106094 @default.
- W1508842216 cites W2058083059 @default.
- W1508842216 cites W2058960821 @default.
- W1508842216 cites W2059114820 @default.
- W1508842216 cites W2059751684 @default.