FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1508848362> ?p ?o ?g. }

• W1508848362 abstract "Abstract Recently, the formation of inclusion bodies in several neurodegenerative diseases, including Parkinson's disease, has been associated with the aggregation of unfolded proteins recruited in the centrosome. We have reported previously that rotenone, an insecticide that is used to produce experimental models of Parkinsonism, induced the aggregation of the α‐synuclein protein in the centrosome, and it notably affected the structure and function of this organelle in primary cultures of mesencephalic neurons and astrocytes. However, it is still obscure the mechanisms through which the disorganization and centrosomal dysfunction could induce cell death. In this study the rat neuroblastoma B65 cell line was chronically exposed to rotenone, and then the distribution of the centrosomal protein γ‐tubulin was studied by immunocytochemistry and Western blot analyses. Finally, the configuration of mitotic spindles and distribution of the p53 protein was observed in the control and rotenone‐treated groups. Rotenone treatment increased the number of cells having centrosome overduplication and multipolar mitotic spindles. In contrast, rotenone induced redistribution of the p53 protein, which was colocalized with the γ‐tubulin protein in the perinuclear region of cells having overduplicated centrosomes. In addition, the p53 positive signal was markedly intense in cells containing aberrant chromosome segregation and micronuclei. Our results suggest that centrosome overduplication may play an important role in the redistribution of the p53 protein in rotenone‐treated cells, and this could represent an alternative mechanism of rotenone to induce apoptosis in neuronal cells." @default.
• W1508848362 created "2016-06-24" @default.
• W1508848362 creator A5026597336 @default.
• W1508848362 creator A5037289392 @default.
• W1508848362 creator A5047524684 @default.
• W1508848362 creator A5050295898 @default.
• W1508848362 creator A5051183900 @default.
• W1508848362 date "2006-03-15" @default.
• W1508848362 modified "2023-10-17" @default.
• W1508848362 title "Centrosome overduplication induced by rotenone treatment affects the cellular distribution of p53 tumor suppressor protein in the neuroblastoma B65 cell line" @default.
• W1508848362 cites W1504584187 @default.
• W1508848362 cites W1527671059 @default.
• W1508848362 cites W1584829548 @default.
• W1508848362 cites W1954514489 @default.
• W1508848362 cites W1973324345 @default.
• W1508848362 cites W1978143866 @default.
• W1508848362 cites W1979915207 @default.
• W1508848362 cites W1981197771 @default.
• W1508848362 cites W1986187456 @default.
• W1508848362 cites W1988146888 @default.
• W1508848362 cites W1993275163 @default.
• W1508848362 cites W1993572893 @default.
• W1508848362 cites W2002506451 @default.
• W1508848362 cites W2004941241 @default.
• W1508848362 cites W2008661368 @default.
• W1508848362 cites W2008917555 @default.
• W1508848362 cites W2014677810 @default.
• W1508848362 cites W2018811378 @default.
• W1508848362 cites W2022089184 @default.
• W1508848362 cites W2033268132 @default.
• W1508848362 cites W2033836694 @default.
• W1508848362 cites W2039129686 @default.
• W1508848362 cites W2047382426 @default.
• W1508848362 cites W2056867819 @default.
• W1508848362 cites W2061258627 @default.
• W1508848362 cites W2083063695 @default.
• W1508848362 cites W2092763133 @default.
• W1508848362 cites W2093221129 @default.
• W1508848362 cites W2098079466 @default.
• W1508848362 cites W2109249715 @default.
• W1508848362 cites W2131081669 @default.
• W1508848362 cites W2143959688 @default.
• W1508848362 cites W2149761960 @default.
• W1508848362 cites W2152693222 @default.
• W1508848362 cites W2152719680 @default.
• W1508848362 cites W2156241187 @default.
• W1508848362 cites W2166830375 @default.
• W1508848362 cites W2167921288 @default.
• W1508848362 cites W2168787545 @default.
• W1508848362 cites W2171715833 @default.
• W1508848362 cites W318206730 @default.
• W1508848362 cites W73030915 @default.
• W1508848362 doi "https://doi.org/10.1111/j.1440-1819.2006.01528.x-i1" @default.
• W1508848362 hasPublicationYear "2006" @default.
• W1508848362 type Work @default.
• W1508848362 sameAs 1508848362 @default.
• W1508848362 citedByCount "3" @default.
• W1508848362 crossrefType "journal-article" @default.
• W1508848362 hasAuthorship W1508848362A5026597336 @default.
• W1508848362 hasAuthorship W1508848362A5037289392 @default.
• W1508848362 hasAuthorship W1508848362A5047524684 @default.
• W1508848362 hasAuthorship W1508848362A5050295898 @default.
• W1508848362 hasAuthorship W1508848362A5051183900 @default.
• W1508848362 hasBestOaLocation W15088483621 @default.
• W1508848362 hasConcept C10447061 @default.
• W1508848362 hasConcept C126322002 @default.
• W1508848362 hasConcept C1491633281 @default.
• W1508848362 hasConcept C20418707 @default.
• W1508848362 hasConcept C2776925932 @default.
• W1508848362 hasConcept C2778389096 @default.
• W1508848362 hasConcept C2779134260 @default.
• W1508848362 hasConcept C28859421 @default.
• W1508848362 hasConcept C29537977 @default.
• W1508848362 hasConcept C55493867 @default.
• W1508848362 hasConcept C71924100 @default.
• W1508848362 hasConcept C84425145 @default.
• W1508848362 hasConcept C86803240 @default.
• W1508848362 hasConcept C93304396 @default.
• W1508848362 hasConcept C95444343 @default.
• W1508848362 hasConceptScore W1508848362C10447061 @default.
• W1508848362 hasConceptScore W1508848362C126322002 @default.
• W1508848362 hasConceptScore W1508848362C1491633281 @default.
• W1508848362 hasConceptScore W1508848362C20418707 @default.
• W1508848362 hasConceptScore W1508848362C2776925932 @default.
• W1508848362 hasConceptScore W1508848362C2778389096 @default.
• W1508848362 hasConceptScore W1508848362C2779134260 @default.
• W1508848362 hasConceptScore W1508848362C28859421 @default.
• W1508848362 hasConceptScore W1508848362C29537977 @default.
• W1508848362 hasConceptScore W1508848362C55493867 @default.
• W1508848362 hasConceptScore W1508848362C71924100 @default.
• W1508848362 hasConceptScore W1508848362C84425145 @default.
• W1508848362 hasConceptScore W1508848362C86803240 @default.
• W1508848362 hasConceptScore W1508848362C93304396 @default.
• W1508848362 hasConceptScore W1508848362C95444343 @default.
• W1508848362 hasIssue "s1" @default.
• W1508848362 hasLocation W15088483621 @default.
• W1508848362 hasOpenAccess W1508848362 @default.
• W1508848362 hasPrimaryLocation W15088483621 @default.
• W1508848362 hasRelatedWork W1988089666 @default.
• W1508848362 hasRelatedWork W2037888696 @default.

• next