Matches in SemOpenAlex for { <https://semopenalex.org/work/W1508915056> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W1508915056 abstract "This novel design represents a broadly applicable three-dimensional technique for fabricating an “organ-on-a-chip” that serves as a viable platform for tissue studies. Current methods of biological research rely on animal testing and two-dimensional tissue cultures, but fail to provide physiologically accurate models of human tissue. This demonstrates a pressing need for convenient, physiologically relevant tissue models to advance biomedical research. Advances in microfluidics and cell encapsulation within hydrogels have made significant strides in trying to meet these needs, but the potential to use these technologies for engineering physiologically relevant tissue models has yet to be fully realized. Here, we present a microfluidic device which will integrate three-dimensional micro-patterned cellular constructs that may be subjected to flow through microfluidic channels. This microphysiological platform takes advantage of microfluidics, cell encapsulation within 3-dimensional constructs, and microscale patterning of different cell types. This creates a spatially patterned co-culture environment which accurately mimics the physiological conditions within many human organs. Here, we aim to model bone tissue, but the developed technology is generally applicable to any tissue or organ in either the healthy or diseased state. This work represents a significant improvement to biomedical research tools and tissue models currently available." @default.
- W1508915056 created "2016-06-24" @default.
- W1508915056 creator A5027449159 @default.
- W1508915056 creator A5035189962 @default.
- W1508915056 creator A5059682998 @default.
- W1508915056 creator A5085033411 @default.
- W1508915056 date "2015-04-01" @default.
- W1508915056 modified "2023-09-24" @default.
- W1508915056 title "Engineering a microfluidic organ model using 3-dimensional micropatterned cellular constructs" @default.
- W1508915056 cites W2013520568 @default.
- W1508915056 cites W2018528089 @default.
- W1508915056 doi "https://doi.org/10.1109/nebec.2015.7117104" @default.
- W1508915056 hasPublicationYear "2015" @default.
- W1508915056 type Work @default.
- W1508915056 sameAs 1508915056 @default.
- W1508915056 citedByCount "0" @default.
- W1508915056 crossrefType "proceedings-article" @default.
- W1508915056 hasAuthorship W1508915056A5027449159 @default.
- W1508915056 hasAuthorship W1508915056A5035189962 @default.
- W1508915056 hasAuthorship W1508915056A5059682998 @default.
- W1508915056 hasAuthorship W1508915056A5085033411 @default.
- W1508915056 hasConcept C108586683 @default.
- W1508915056 hasConcept C127413603 @default.
- W1508915056 hasConcept C136229726 @default.
- W1508915056 hasConcept C145420912 @default.
- W1508915056 hasConcept C165932988 @default.
- W1508915056 hasConcept C171250308 @default.
- W1508915056 hasConcept C179428855 @default.
- W1508915056 hasConcept C183696295 @default.
- W1508915056 hasConcept C188027245 @default.
- W1508915056 hasConcept C192562407 @default.
- W1508915056 hasConcept C33923547 @default.
- W1508915056 hasConcept C41008148 @default.
- W1508915056 hasConcept C49892992 @default.
- W1508915056 hasConcept C8673954 @default.
- W1508915056 hasConceptScore W1508915056C108586683 @default.
- W1508915056 hasConceptScore W1508915056C127413603 @default.
- W1508915056 hasConceptScore W1508915056C136229726 @default.
- W1508915056 hasConceptScore W1508915056C145420912 @default.
- W1508915056 hasConceptScore W1508915056C165932988 @default.
- W1508915056 hasConceptScore W1508915056C171250308 @default.
- W1508915056 hasConceptScore W1508915056C179428855 @default.
- W1508915056 hasConceptScore W1508915056C183696295 @default.
- W1508915056 hasConceptScore W1508915056C188027245 @default.
- W1508915056 hasConceptScore W1508915056C192562407 @default.
- W1508915056 hasConceptScore W1508915056C33923547 @default.
- W1508915056 hasConceptScore W1508915056C41008148 @default.
- W1508915056 hasConceptScore W1508915056C49892992 @default.
- W1508915056 hasConceptScore W1508915056C8673954 @default.
- W1508915056 hasLocation W15089150561 @default.
- W1508915056 hasOpenAccess W1508915056 @default.
- W1508915056 hasPrimaryLocation W15089150561 @default.
- W1508915056 hasRelatedWork W1953417596 @default.
- W1508915056 hasRelatedWork W2030450624 @default.
- W1508915056 hasRelatedWork W2032758002 @default.
- W1508915056 hasRelatedWork W2042992678 @default.
- W1508915056 hasRelatedWork W2053293963 @default.
- W1508915056 hasRelatedWork W2069464566 @default.
- W1508915056 hasRelatedWork W2259451623 @default.
- W1508915056 hasRelatedWork W2305501510 @default.
- W1508915056 hasRelatedWork W2401271030 @default.
- W1508915056 hasRelatedWork W2599323335 @default.
- W1508915056 hasRelatedWork W2599863456 @default.
- W1508915056 hasRelatedWork W2766601883 @default.
- W1508915056 hasRelatedWork W2907053892 @default.
- W1508915056 hasRelatedWork W2941421140 @default.
- W1508915056 hasRelatedWork W2941657522 @default.
- W1508915056 hasRelatedWork W2947060851 @default.
- W1508915056 hasRelatedWork W2951165982 @default.
- W1508915056 hasRelatedWork W3011009170 @default.
- W1508915056 hasRelatedWork W3112584587 @default.
- W1508915056 hasRelatedWork W3172073147 @default.
- W1508915056 isParatext "false" @default.
- W1508915056 isRetracted "false" @default.
- W1508915056 magId "1508915056" @default.
- W1508915056 workType "article" @default.