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- W150897209 abstract "The link between competing death risks and the change of risk factorlevels over time has been analysed using data from the Zutphen-Study andthe model of Manton&Stallard. The Zutphen-cohort consists of 878 men,initially with te ages of 40-59 years, that have been followed since1960. The model of Manton&Stallard describes the change of thedistribution of the risk factor levels of a cohort over time taking intoaccount mortality and the change of levesl within individuals. Thehazard function used is similar to the one used in the Cox proportionalhazards model. For almost the same combinations of risk factors andcauses of death significant effects have been found as in Cox analyses. However, using current instead of baseline risk factor measurement valuesresult in smaller effects probably due to medication (for totalcholesterol and systolic bloodpressure) or in larger effects probably dueto a reverse causal relation (for BMI and lung cancer). The mostinteresting and striking rsults were found with respect to the riskfactor changes over age. We found positive age-trends for all riskfactors (although non-significant for cholesterol), whereas the resultsof simple regression analyses were not that clear. More specific resultsrelate to the interactions with respect to the deterministic and randomchanges. The results of the analyses will be used for the furtherdevelopment of the chronic diseases modelling tools. That means, therefinement of the modelling of the changes of the risk factors mentionedabove over age, and the relation (interaction) between theschanges" @default.
- W150897209 created "2016-06-24" @default.
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- W150897209 date "2000-06-16" @default.
- W150897209 modified "2023-09-27" @default.
- W150897209 title "Ageing and mortality. Results from theZutphen-Study" @default.
- W150897209 hasPublicationYear "2000" @default.
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