Matches in SemOpenAlex for { <https://semopenalex.org/work/W1508994608> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W1508994608 endingPage "15927" @default.
- W1508994608 startingPage "15923" @default.
- W1508994608 abstract "The effects of growth hormone on the expression of sex-dependent testosterone 16 alpha- and 15 alpha-hydroxylases were studied in growth hormone-deficient Little (lit/lit) mice at the activity as well as at the mRNA levels. The male isozyme of testosterone 16 alpha-hydroxylase (C-P-450(16)alpha) was repressed in the liver of male lit/lit mice, and the injection of bovine growth hormone resulted in an increase of the isozyme at both activity and mRNA levels to those seen in control lit/+ male mice. On the other hand, the female isozymes of testosterone 16 alpha- (I-P-450(16)alpha) and 15 alpha-hydroxylase (P-450(15)alpha) were increased in livers of both male and female lit/lit mice. The increased I-P-450(16)alpha and P-450(15)alpha in lit/lit mice were suppressed by growth hormone but only when it was injected once every 12 h. Thus, the results indicate that growth hormone acts as a masculinizing factor for testosterone hydroxylase activity by activating and inhibiting the expression of male and female isozymes of testosterone hydroxylases in mice, respectively. When growth hormone was infused to simulate a continuous secretion pattern, it showed no significant effect on the expression of hydroxylases in lit/lit mice, suggesting that growth hormone may not be a feminizing factor for testosterone hydroxylase activity in female mice. The changes of specific hydroxylase activities modulated by growth hormone in the mice correlated well with those amounts of hydroxylase mRNAs. The action of exogenous growth hormone to regulate the hydroxylases was so slow that it took 2 days to show a significant effect." @default.
- W1508994608 created "2016-06-24" @default.
- W1508994608 creator A5089629096 @default.
- W1508994608 creator A5089637555 @default.
- W1508994608 date "1986-12-01" @default.
- W1508994608 modified "2023-10-15" @default.
- W1508994608 title "Pretranslational regulation of sex-dependent testosterone hydroxylases by growth hormone in mouse liver." @default.
- W1508994608 cites W1492298052 @default.
- W1508994608 cites W1508610451 @default.
- W1508994608 cites W1536089744 @default.
- W1508994608 cites W1552736699 @default.
- W1508994608 cites W1558252306 @default.
- W1508994608 cites W1581192127 @default.
- W1508994608 cites W158373933 @default.
- W1508994608 cites W1591476755 @default.
- W1508994608 cites W1951469402 @default.
- W1508994608 cites W1965066812 @default.
- W1508994608 cites W1967382710 @default.
- W1508994608 cites W1970046944 @default.
- W1508994608 cites W1971807649 @default.
- W1508994608 cites W1995617105 @default.
- W1508994608 cites W1996398049 @default.
- W1508994608 cites W2001918644 @default.
- W1508994608 cites W2024136373 @default.
- W1508994608 cites W2025675183 @default.
- W1508994608 cites W2037816029 @default.
- W1508994608 cites W2044906551 @default.
- W1508994608 cites W2066160869 @default.
- W1508994608 cites W2068309907 @default.
- W1508994608 cites W2070466287 @default.
- W1508994608 cites W2094230228 @default.
- W1508994608 cites W2100662634 @default.
- W1508994608 cites W2317375044 @default.
- W1508994608 cites W233730272 @default.
- W1508994608 cites W4239402702 @default.
- W1508994608 cites W4293247451 @default.
- W1508994608 doi "https://doi.org/10.1016/s0021-9258(18)66653-0" @default.
- W1508994608 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3782098" @default.
- W1508994608 hasPublicationYear "1986" @default.
- W1508994608 type Work @default.
- W1508994608 sameAs 1508994608 @default.
- W1508994608 citedByCount "81" @default.
- W1508994608 countsByYear W15089946082014 @default.
- W1508994608 countsByYear W15089946082016 @default.
- W1508994608 countsByYear W15089946082017 @default.
- W1508994608 countsByYear W15089946082023 @default.
- W1508994608 crossrefType "journal-article" @default.
- W1508994608 hasAuthorship W1508994608A5089629096 @default.
- W1508994608 hasAuthorship W1508994608A5089637555 @default.
- W1508994608 hasBestOaLocation W15089946081 @default.
- W1508994608 hasConcept C126322002 @default.
- W1508994608 hasConcept C134018914 @default.
- W1508994608 hasConcept C185592680 @default.
- W1508994608 hasConcept C2777911890 @default.
- W1508994608 hasConcept C2779279991 @default.
- W1508994608 hasConcept C2984496839 @default.
- W1508994608 hasConcept C30092816 @default.
- W1508994608 hasConcept C71315377 @default.
- W1508994608 hasConcept C71924100 @default.
- W1508994608 hasConcept C86803240 @default.
- W1508994608 hasConceptScore W1508994608C126322002 @default.
- W1508994608 hasConceptScore W1508994608C134018914 @default.
- W1508994608 hasConceptScore W1508994608C185592680 @default.
- W1508994608 hasConceptScore W1508994608C2777911890 @default.
- W1508994608 hasConceptScore W1508994608C2779279991 @default.
- W1508994608 hasConceptScore W1508994608C2984496839 @default.
- W1508994608 hasConceptScore W1508994608C30092816 @default.
- W1508994608 hasConceptScore W1508994608C71315377 @default.
- W1508994608 hasConceptScore W1508994608C71924100 @default.
- W1508994608 hasConceptScore W1508994608C86803240 @default.
- W1508994608 hasIssue "34" @default.
- W1508994608 hasLocation W15089946081 @default.
- W1508994608 hasOpenAccess W1508994608 @default.
- W1508994608 hasPrimaryLocation W15089946081 @default.
- W1508994608 hasRelatedWork W1973974195 @default.
- W1508994608 hasRelatedWork W2021632148 @default.
- W1508994608 hasRelatedWork W2040200387 @default.
- W1508994608 hasRelatedWork W2103054709 @default.
- W1508994608 hasRelatedWork W2132426768 @default.
- W1508994608 hasRelatedWork W2137310767 @default.
- W1508994608 hasRelatedWork W2301810742 @default.
- W1508994608 hasRelatedWork W2352524410 @default.
- W1508994608 hasRelatedWork W2390717769 @default.
- W1508994608 hasRelatedWork W2748952813 @default.
- W1508994608 hasVolume "261" @default.
- W1508994608 isParatext "false" @default.
- W1508994608 isRetracted "false" @default.
- W1508994608 magId "1508994608" @default.
- W1508994608 workType "article" @default.