Matches in SemOpenAlex for { <https://semopenalex.org/work/W1509002146> ?p ?o ?g. }
- W1509002146 endingPage "530" @default.
- W1509002146 startingPage "518" @default.
- W1509002146 abstract "Neuronal nicotinic acetylcholine receptors (nAChRs) containing the α3 subunit are known for their prominent role in normal ganglionic transmission while their involvement in the mechanisms underlying nicotine addiction and smoking-related disease has been emerging only in recent years. The amount of information available on the maturation and trafficking of α3-containing nAChRs is limited. We previously showed that UBXN2A is a p97 adaptor protein that facilitates the maturation and trafficking of α3-containing nAChRs. Further investigation of the mechanisms of UBXN2A actions revealed that the protein interacts with CHIP (carboxyl terminus of Hsc70 interacting protein), whose ubiquitin E3 ligase activity regulates the degradation of several disease-related proteins. We show that CHIP displays E3 ligase activity toward the α3 nAChR subunit and contributes to its ubiquitination and subsequent degradation. UBXN2A interferes with CHIP-mediated ubiquitination of α3 and protects the nicotinic receptor subunit from endoplasmic reticulum associated degradation (ERAD). UBXN2A also cross-talks with VCP/p97 and HSC70/HSP70 proteins in a complex where α3 is likely to be targeted by CHIP. Overall,we identify CHIP as an E3 ligase for α3 and UBXN2A as a protein that may efficiently regulate the stability of CHIP’s client substrates." @default.
- W1509002146 created "2016-06-24" @default.
- W1509002146 creator A5029318173 @default.
- W1509002146 creator A5057815689 @default.
- W1509002146 creator A5089699394 @default.
- W1509002146 date "2015-10-01" @default.
- W1509002146 modified "2023-09-23" @default.
- W1509002146 title "UBXN2A regulates nicotinic receptor degradation by modulating the E3 ligase activity of CHIP" @default.
- W1509002146 cites W1520171546 @default.
- W1509002146 cites W1527254461 @default.
- W1509002146 cites W1556409059 @default.
- W1509002146 cites W1556426431 @default.
- W1509002146 cites W1605149529 @default.
- W1509002146 cites W1814703135 @default.
- W1509002146 cites W1966993307 @default.
- W1509002146 cites W1972020976 @default.
- W1509002146 cites W1972280410 @default.
- W1509002146 cites W1975536724 @default.
- W1509002146 cites W1977479344 @default.
- W1509002146 cites W1981551685 @default.
- W1509002146 cites W1986186343 @default.
- W1509002146 cites W1986854952 @default.
- W1509002146 cites W1991989590 @default.
- W1509002146 cites W2001438747 @default.
- W1509002146 cites W2001788282 @default.
- W1509002146 cites W2004010541 @default.
- W1509002146 cites W2006454434 @default.
- W1509002146 cites W2007731984 @default.
- W1509002146 cites W2008738874 @default.
- W1509002146 cites W2009498504 @default.
- W1509002146 cites W2010862596 @default.
- W1509002146 cites W2011269026 @default.
- W1509002146 cites W2011325147 @default.
- W1509002146 cites W2014697177 @default.
- W1509002146 cites W2017764563 @default.
- W1509002146 cites W2018462246 @default.
- W1509002146 cites W2019110389 @default.
- W1509002146 cites W2022569735 @default.
- W1509002146 cites W2025960774 @default.
- W1509002146 cites W2028997060 @default.
- W1509002146 cites W2030075669 @default.
- W1509002146 cites W2031027239 @default.
- W1509002146 cites W2031259748 @default.
- W1509002146 cites W2032551306 @default.
- W1509002146 cites W2038449857 @default.
- W1509002146 cites W2039070628 @default.
- W1509002146 cites W2040833814 @default.
- W1509002146 cites W2047455709 @default.
- W1509002146 cites W2047598222 @default.
- W1509002146 cites W2049127225 @default.
- W1509002146 cites W2052885679 @default.
- W1509002146 cites W2054943429 @default.
- W1509002146 cites W2058252917 @default.
- W1509002146 cites W2064609154 @default.
- W1509002146 cites W2065825563 @default.
- W1509002146 cites W2068450558 @default.
- W1509002146 cites W2068521481 @default.
- W1509002146 cites W2069183580 @default.
- W1509002146 cites W2072803101 @default.
- W1509002146 cites W2073337768 @default.
- W1509002146 cites W2077314520 @default.
- W1509002146 cites W2077445010 @default.
- W1509002146 cites W2080729278 @default.
- W1509002146 cites W2083081815 @default.
- W1509002146 cites W2085120361 @default.
- W1509002146 cites W2087839913 @default.
- W1509002146 cites W2089925321 @default.
- W1509002146 cites W2090092693 @default.
- W1509002146 cites W2102487178 @default.
- W1509002146 cites W2103233885 @default.
- W1509002146 cites W2106506181 @default.
- W1509002146 cites W2107442883 @default.
- W1509002146 cites W2108344795 @default.
- W1509002146 cites W2115093402 @default.
- W1509002146 cites W2115108491 @default.
- W1509002146 cites W2115894732 @default.
- W1509002146 cites W2116511323 @default.
- W1509002146 cites W2118082971 @default.
- W1509002146 cites W2120476812 @default.
- W1509002146 cites W2122791877 @default.
- W1509002146 cites W2122934231 @default.
- W1509002146 cites W2124863921 @default.
- W1509002146 cites W2126762966 @default.
- W1509002146 cites W2128306943 @default.
- W1509002146 cites W2128682283 @default.
- W1509002146 cites W2130038381 @default.
- W1509002146 cites W2133406524 @default.
- W1509002146 cites W2136452399 @default.
- W1509002146 cites W2139174700 @default.
- W1509002146 cites W2141018705 @default.
- W1509002146 cites W2153961293 @default.
- W1509002146 cites W2153982845 @default.
- W1509002146 cites W2154979583 @default.
- W1509002146 cites W2158494234 @default.
- W1509002146 cites W2159641975 @default.
- W1509002146 cites W2162967253 @default.
- W1509002146 cites W2164238960 @default.
- W1509002146 cites W2165425515 @default.