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- W1509072483 endingPage "402" @default.
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- W1509072483 abstract "Abstract Glucagon‐like peptide‐1 ( GLP ‐1) is the primary incretin hormone secreted from the intestine upon uptake of food to stimulate insulin secretion from pancreatic β ‐cells. GLP ‐1 exerts its effects by binding to its G ‐protein coupled receptors and subsequently activating adenylate cyclase, leading to generation of cyclic adenosine monophosphate ( cAMP ). cAMP stimulates insulin secretion via activation of its effectors PKA and E pac2 in pancreatic β ‐cells. In addition to its insulinotropic effects, GLP ‐1 also preserves pancreatic β ‐cell mass by stimulating β ‐cell proliferation. Unlike the action of sulphonylureas in lowering blood glucose levels, action of GLP ‐1 is affected by and interplays with glucose levels. Due to such advantages, GLP ‐1‐based therapeutics have been rapidly developed and used clinically for treatment of type 2 diabetes. However, molecular mechanisms underlying how GLP ‐1 potentiates diminished glucose‐stimulated insulin secretion and β ‐cell proliferation under diabetic conditions are not well understood. Here, we review the actions of GLP ‐1 in regulation of insulin secretion and pancreatic β ‐cell proliferation." @default.
- W1509072483 created "2016-06-24" @default.
- W1509072483 creator A5010558103 @default.
- W1509072483 creator A5030473640 @default.
- W1509072483 creator A5057826903 @default.
- W1509072483 date "2014-05-22" @default.
- W1509072483 modified "2023-10-16" @default.
- W1509072483 title "Glucagon‐like peptide 1‐potentiated insulin secretion and proliferation of pancreatic <i>β</i>‐cells GLP‐1促进胰岛素分泌和胰岛<i>β</i>细胞增殖的机制" @default.
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