Matches in SemOpenAlex for { <https://semopenalex.org/work/W1509184419> ?p ?o ?g. }
- W1509184419 endingPage "6101" @default.
- W1509184419 startingPage "6090" @default.
- W1509184419 abstract "Despite recent evidence on the involvement of CD81 in pathogen binding and Ag presentation by dendritic cells (DCs), the molecular mechanism of how CD81 regulates immunity during infection remains to be elucidated. To investigate the role of CD81 in the regulation of defense mechanisms against microbial infections, we have used the Listeria monocytogenes infection model to explore the impact of CD81 deficiency in the innate and adaptive immune response against this pathogenic bacteria. We show that CD81(-/-) mice are less susceptible than wild-type mice to systemic Listeria infection, which correlates with increased numbers of inflammatory monocytes and DCs in CD81(-/-) spleens, the main subsets controlling early bacterial burden. Additionally, our data reveal that CD81 inhibits Rac/STAT-1 activation, leading to a negative regulation of the production of TNF-α and NO by inflammatory DCs and the activation of cytotoxic T cells by splenic CD8α(+) DCs. In conclusion, this study demonstrates that CD81-Rac interaction exerts an important regulatory role on the innate and adaptive immunity against bacterial infection and suggests a role for CD81 in the development of novel therapeutic targets during infectious diseases." @default.
- W1509184419 created "2016-06-24" @default.
- W1509184419 creator A5004084848 @default.
- W1509184419 creator A5017534042 @default.
- W1509184419 creator A5029395728 @default.
- W1509184419 creator A5035093031 @default.
- W1509184419 creator A5042124020 @default.
- W1509184419 creator A5066670004 @default.
- W1509184419 creator A5069062726 @default.
- W1509184419 creator A5077495940 @default.
- W1509184419 creator A5084727753 @default.
- W1509184419 creator A5089223077 @default.
- W1509184419 creator A5089967069 @default.
- W1509184419 date "2015-06-15" @default.
- W1509184419 modified "2023-10-18" @default.
- W1509184419 title "CD81 Controls Immunity to <i>Listeria</i> Infection through Rac-Dependent Inhibition of Proinflammatory Mediator Release and Activation of Cytotoxic T Cells" @default.
- W1509184419 cites W1529804111 @default.
- W1509184419 cites W1539725533 @default.
- W1509184419 cites W1548370164 @default.
- W1509184419 cites W1551883442 @default.
- W1509184419 cites W1950176298 @default.
- W1509184419 cites W1968807810 @default.
- W1509184419 cites W1973331566 @default.
- W1509184419 cites W1977323533 @default.
- W1509184419 cites W1982146374 @default.
- W1509184419 cites W1983947761 @default.
- W1509184419 cites W1985295306 @default.
- W1509184419 cites W1990083653 @default.
- W1509184419 cites W1994640931 @default.
- W1509184419 cites W1997384271 @default.
- W1509184419 cites W1998670692 @default.
- W1509184419 cites W2002048532 @default.
- W1509184419 cites W2003107797 @default.
- W1509184419 cites W2005884645 @default.
- W1509184419 cites W2012319233 @default.
- W1509184419 cites W2012972393 @default.
- W1509184419 cites W2013094398 @default.
- W1509184419 cites W2017870917 @default.
- W1509184419 cites W2038034818 @default.
- W1509184419 cites W2040120073 @default.
- W1509184419 cites W2042751933 @default.
- W1509184419 cites W2043019041 @default.
- W1509184419 cites W2045971973 @default.
- W1509184419 cites W2056628849 @default.
- W1509184419 cites W2057138015 @default.
- W1509184419 cites W2057521728 @default.
- W1509184419 cites W2063186096 @default.
- W1509184419 cites W2070026001 @default.
- W1509184419 cites W2073733645 @default.
- W1509184419 cites W2074510255 @default.
- W1509184419 cites W2077084122 @default.
- W1509184419 cites W2077509904 @default.
- W1509184419 cites W2078710631 @default.
- W1509184419 cites W2088083691 @default.
- W1509184419 cites W2091129202 @default.
- W1509184419 cites W2092233799 @default.
- W1509184419 cites W2093306132 @default.
- W1509184419 cites W2095751049 @default.
- W1509184419 cites W2105403316 @default.
- W1509184419 cites W2111253543 @default.
- W1509184419 cites W2117299062 @default.
- W1509184419 cites W2122822209 @default.
- W1509184419 cites W2123093878 @default.
- W1509184419 cites W2130578430 @default.
- W1509184419 cites W2140198264 @default.
- W1509184419 cites W2141295922 @default.
- W1509184419 cites W2149779118 @default.
- W1509184419 cites W2160174559 @default.
- W1509184419 cites W2165352885 @default.
- W1509184419 cites W2168795664 @default.
- W1509184419 cites W2283167609 @default.
- W1509184419 doi "https://doi.org/10.4049/jimmunol.1402957" @default.
- W1509184419 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25972472" @default.
- W1509184419 hasPublicationYear "2015" @default.
- W1509184419 type Work @default.
- W1509184419 sameAs 1509184419 @default.
- W1509184419 citedByCount "13" @default.
- W1509184419 countsByYear W15091844192016 @default.
- W1509184419 countsByYear W15091844192017 @default.
- W1509184419 countsByYear W15091844192018 @default.
- W1509184419 countsByYear W15091844192020 @default.
- W1509184419 countsByYear W15091844192021 @default.
- W1509184419 countsByYear W15091844192023 @default.
- W1509184419 crossrefType "journal-article" @default.
- W1509184419 hasAuthorship W1509184419A5004084848 @default.
- W1509184419 hasAuthorship W1509184419A5017534042 @default.
- W1509184419 hasAuthorship W1509184419A5029395728 @default.
- W1509184419 hasAuthorship W1509184419A5035093031 @default.
- W1509184419 hasAuthorship W1509184419A5042124020 @default.
- W1509184419 hasAuthorship W1509184419A5066670004 @default.
- W1509184419 hasAuthorship W1509184419A5069062726 @default.
- W1509184419 hasAuthorship W1509184419A5077495940 @default.
- W1509184419 hasAuthorship W1509184419A5084727753 @default.
- W1509184419 hasAuthorship W1509184419A5089223077 @default.
- W1509184419 hasAuthorship W1509184419A5089967069 @default.
- W1509184419 hasBestOaLocation W15091844191 @default.
- W1509184419 hasConcept C136449434 @default.
- W1509184419 hasConcept C154317977 @default.