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- W15092010 abstract "This chapter discusses the role of free oxygen radicals in the activation of the natural killer (NK) cytolytic pathway. The cytolytic pathway can be divided into four discrete stages, which include recognition and binding to the target and triggering and activation of the lytic mechanisms. An examination of low-NK responsiveness in humans has shown that individuals with this stable, selective defect have normal frequencies of HNK-1+ NK cells, which bind normally to the tumor targets and are boosted normally by interferon but fail to become activated as judged by a 60% decrease in the burst of oxygen radicals that are normally generated following target–effector interaction. The data suggest that the generation of oxygen radicals is an early event in the triggering and activation of the lytic mechanism, stage 2. The block in NK cytolysis appears to be in stage 3 because binding to the target is normal and is followed by normal triggering and production of oxygen radicals, thereby indicating that the oxygen radicals normally appear prior to the step in the cytolytic pathway, which is blocked in the Chediak–Higashi syndrome." @default.
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- W15092010 date "1982-01-01" @default.
- W15092010 modified "2023-09-25" @default.
- W15092010 title "THE ROLE OF FREE OXYGEN RADICALS IN THE ACTIVATION OF THE NK CYTOLYTIC PATHWAY" @default.
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- W15092010 doi "https://doi.org/10.1016/b978-0-12-341360-4.50150-5" @default.
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