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- W1509203614 abstract "Mutants of two strains of Newcastle disease virus which differ from each other in three characteristics (plaque type, heat stability, and serotype) were used to mixedly infect chick embryo cells at high multiplicities. After plating out mixed yields, 90% of the plaques were found to contain only one parental virus type but 10% contained both parental types and experiments indicate that these mixed plaques were initiated by heterozygous particles which were probably diploid. A high proportion of the particles from mixed infections showed evidence of phenotypic mixing both in respect to serotype and thermal stability. When the fluid from mixed infections was used to singly infect cells, there were large numbers of phenotypically mixed particles in the yield. The amount of phenotypic mixing could be accounted for by the number of heterozygotes in the inoculum. Mixed infections at low multiplicities yielded five to ten times as much phenotypically mixed virus as could be accounted for by the number of cells expected to be mixedly infected by two plaque-forming particles. The results suggest that nonplaque-forming particles may contribute to the phenotype of new virus induced by infection with plaque-forming virus." @default.
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- W1509203614 date "1959-12-01" @default.
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- W1509203614 title "Studies on mixed infection with Newcastle disease virus" @default.
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- W1509203614 doi "https://doi.org/10.1016/0042-6822(59)90155-2" @default.
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