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- W1509233722 abstract "Article1 February 1960THE OXYHEMOGLOBIN DISSOCIATION CURVE IN ANEMIATHEODORE RODMAN, M.D., HENRY P. CLOSE, M.D., F.A.C.P., MAY K. PURCELLTHEODORE RODMAN, M.D.Search for more papers by this author, HENRY P. CLOSE, M.D., F.A.C.P.Search for more papers by this author, MAY K. PURCELLSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-52-2-295 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe primary function of hemoglobin is the transport of oxygen from the lungs to the tissues. Anemia compromises this transport mechanism and exposes the tissues to the dangers of hypoxia. The fact that patients with slowly developing anemia are frequently symptom-free with low levels of circulating hemoglobin strongly suggests that efficient compensatory mechanisms are available to provide an adequate supply of oxygen to the tissues. There are two generally recognized compensatory mechanisms: a reduced tissue oxygen tension, which results in more nearly complete extraction of oxygen from the blood, and an increased cardiac output. Both of these mechanisms entail disadvantages—a...Bibliography1. FraimowRodmanCloseCathcartPurcell WTHPRMK: The oxyhemoglobin dissociation curve in sickle cell anemia, Am. J. M. Sc. 236: 225-232, 1958. CrossrefMedlineGoogle Scholar2. RodmanCloseCathcartPurcell THPRMK: The oxyhemoglobin dissociation curve in the common hemoglobinopathies, Am. J. Med. 27: 558-566, 1959. CrossrefMedlineGoogle Scholar3. RichardsStrauss DWML: The oxyhemoglobin dissociation curves of whole blood in anemia, J. Clin. Investigation 4: 105-126, 1927. CrossrefMedlineGoogle Scholar4. KennedyValtis ACDJ: The oxygen dissociation curve in anemia of various types, J. Clin. Investigation 33: 1372-1381, 1954. CrossrefMedlineGoogle Scholar5. RileyProemmelFranke RLDDRE: Direct method for determination of oxygen and carbon dioxide tensions in blood, J. Biol. Chem. 161: 621-633, 1945. CrossrefMedlineGoogle Scholar6. RydellHoffbauer RFW: Multiple pulmonary arteriovenous fistulas in juvenile cirrhosis, Am. J. Med. 21: 450-460, 1956. CrossrefMedlineGoogle Scholar7. DillBockvon CaulaertFöllingHurxthalHenderson DBAVCALMLJ: Blood as a physicochemical system. VII. The composition and respiratory exchanges of human blood during recovery from pernicious anemia, J. Biol. Chem. 78: 191-214, 1928. CrossrefGoogle Scholar8. HampsonMaizels ACM: The difference of pH between plasma and red cells, J. Physiol. 64: xx-xxii, 1927-28. Google Scholar9. RyanHickam JMJB: The alveolar-arterial oxygen pressure gradient in anemia, J. Clin. Investigation 31: 188-191, 1952. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pennsylvania*Received for publication May 16, 1959.Presented at the Fortieth Annual Session of The American College of Physicians, Chicago, Illinois, April 22, 1959.From the Medical Service and Cardio-pulmonary Division of the Medical Research Laboratory, Philadelphia Veterans Administration Hospital.With the technical assistance of GERTRUDE STILL, A.B., Philadelphia, Pennsylvania.Requests for reprints should be addressed to Theodore Rodman, M.D., Medical Service, Philadelphia Veterans Administration Hospital, Philadelphia 4, Pennsylvania. 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VII Armadillo (Dasypus novemcinctus)The Oxygen Affinity of Haemoglobin in Chronic Renal FailureChanges in Umbilical-Cord Blood Oxygen Affinity after Intrauterine Transfusions for ErythroblastosisMean Red Cell Age as a Determinant of Blood Oxygen AffinityChanges in blood oxygen affinity and hemodynamics in anemic dogsAUTOLOGOUS TRANSFUSIONS IN URÆMIC PATIENTSOxygen transport in human subjects with hemoglobin variants having altered oxygen affinityAdaptation to HypoxiaRed Cell 2,3 DPG, ATP, and Creatine Levels in Preserved Red Cells and in Patients with Red Cell Mass Deficits or with Cardiopulmonary InsufficiencyErythrocyte Glycolytic Intermediates and Cofactors Correlated with the Haemoglobin Concentration in Human Neonates and AdultsThe oxygen-releasing capacity of haemoglobin in patients with severe skin burnsThe Erythrocyte as a Vehicle for Oxygen with Self-regulating Adjustment of UnloadingLagever�nderungen der Sauerstoffbindungskurve in Abh�ngigkeit von den intraerythrocyt�ren Kationen- und H�moglobinkonzentrationenDie Atmungsfunktion des Blutes nach akuter schwerer HämorrhagieDecreased Affinity of Blood for Oxygen in Patients with Low-Output Heart FailureEffect of chronic hypoxic hypoxia on the O2-Hb dissociation curve and respiratory gas transport in manThe Hemodynamic Response to Chronic AnemiaPhysiologie und Pathophysiologie des Sauerstofftransportes im BlutDie Atmungsfunktion des Blutes nach akuter schwerer HämorrhagieOxygen Affinity and Acid-Base Status of Human Blood during Exposure to Hypoxia and Carbon MonoxideOxygen Affinity of Hemoglobin in Patients with Cardiovascular Diseases, Anemia, and Cirrhosis of the LiverThe oxygen supply of the myocardium in acute anemia caused by partial replacement of the blood by polyglucinBone Marrow Gas Tensions, Bone Marrow Blood Flow, and Erythropoiesis in ManJOSEPH L. GRANT, M.D., F.A.C.P., BARRY SMITH, M.D. 1 February 1960Volume 52, Issue 2Page: 295-309KeywordsAnemiaBloodCardiac outputHemoglobinHypoxiaLungsMedical servicesOxygenOxyhemoglobinResearch laboratories Issue Published: 1 February 1960 PDF downloadLoading ..." @default.
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