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- W1509298478 abstract "The fate of tryptophan in the isolated perfused rat liver was investigated. It was shown that the liver removed the L-isomer more rapidly from the perfusate than the D-isomer. The 10 g liver was capable of a removal rate of 35 mg/hour when 42 mg of DL-tryptophan was given initially, followed by infusion at the rate of 42 mg/hour. Carbon-14 from DL-tryptophan-2-14C appeared in CO2 much more rapidly and to a greater extent within 3 hours than did that from DL-tryptophan-7a-14C. In contrast to whole-animal studies, it was shown that overloading doses of acetoacetate were labeled by DL-tryptophan-5- or 7a-14C. The labeling pattern in acetoacetate was similar to that observed when 14C-fatty acids are the substrate. Acetoacetate overloading suppressed the production of radioactive carbon dioxide from DL-tryptophan-7a-14C." @default.
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- W1509298478 date "1969-12-01" @default.
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- W1509298478 title "Metabolism of Tryptophan in Isolated Perfused Rat Liver" @default.
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- W1509298478 doi "https://doi.org/10.1093/jn/99.4.465" @default.
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