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- W1509309743 abstract "Preeclampsia (PE) is associated with hypertension, oxidative stress, and chronic inflammation. The RUPP rat model of PE and normal pregnant (NP) recipient rats of RUPP CD4+T cells exhibit much of the disease pathology. Reactive oxygen species (ROS) could be released from monocytes or neutropils, however the objective of this study was to determine if RUPP CD4 T cells are a cellular source of ROS and hypertension (MAP) and during pregnancy. CD4+Tcells from RUPP rats were injected into NP recipients on gestational day (GD)13; GD19 MAP, urine and tissues were analyzed. Prior to injection RUPP CD4+ T cells secreted more myleoperoxidase compared to NP (116.9+15.2 vs. 48.5+8.3 ng/mg/mL; p=0.003). Placental NADPH oxidase mediated ROS in RUPP rats was 830.6+68, 726.2+43.73 in NP + RUPP CD4+ T cells and 420.7+51.4 RLU/min/mg in NP rats; p=0.009 and p=0.004, respectively. MAP was 100+2 in NP rats, 126+4 in RUPP rats (p=0.0001) and 118+4mmHg in NP+RUPP CD4+ T cell rats (p=0.002) which was attenuated with apocynin; 111+2 in RUPP + apocynin; 102+3 mmHg in NP + RUPP CD4+ T cells (p=0.01). These data suggest that CD4+Tcells are an important source of ROS mediating hypertension in response to placental ischemia. Grant Funding Source: NIH NICHD; APS STRIDE" @default.
- W1509309743 created "2016-06-24" @default.
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- W1509309743 date "2014-04-01" @default.
- W1509309743 modified "2023-09-27" @default.
- W1509309743 title "Oxidative stress signaling in response to CD 4+ T cells stimulated via placental ischemia play an important role in hypertension during preeclampsia (860.14)" @default.
- W1509309743 doi "https://doi.org/10.1096/fasebj.28.1_supplement.860.14" @default.
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