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- W1509462616 abstract "Inhibitors of DNA synthesis interfere with the meiotic cycle if administered to cells during zygonema and/or pachynema. The cytological effects correlate with the chemical evidence for a synthesis of DNA during that same interval. The main effects of inhibiting DNA synthesis are either zygonema arrest or fragmentation of chromosomes. The type of abnormality depends upon the time at which inhibition is effected. Zygonema arrest occurs only if DNA synthesis is inhibited at the time of its initiation which is coincident with the initiation of pairing. Fragmentation of prophase chromosomes occurs only if DNA synthesis is inhibited during mid-zygonema. Inhibition of DNA synthesis during late zygonema or early pachynema does not interfere with the first meiotic division but results in chromosome fragmentation during the second division. The relevance of these observations to chromosome structure is discussed." @default.
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- W1509462616 date "1967-07-01" @default.
- W1509462616 modified "2023-10-17" @default.
- W1509462616 title "Studies of meiosis in vitro" @default.
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- W1509462616 doi "https://doi.org/10.1016/0012-1606(67)90017-6" @default.
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