Matches in SemOpenAlex for { <https://semopenalex.org/work/W1509487799> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W1509487799 abstract "Regulatory T cells (Tregs) are important in controlling skin inflammation, an effect dependent on their ability to home to this organ. However, little is known regarding their behavior in the skin. Here we used multiphoton imaging in Foxp3-GFP mice to examine the behavior of endogenous Tregs in skin. While Tregs were readily detectable in the uninflamed dermis, most were non-motile. Induction of contact sensitivity increased the proportion of motile Tregs, as well as inducing Treg recruitment. This response was significantly blunted in mice challenged with an irrelevant hapten, and by inhibition of effector cell recruitment, indicating a role for T cell-dependent inflammation in induction of Treg migration. Moreover, induction of Treg migration was inhibited by local injection of a CCR4 antagonist, indicating a role for CCR4 in this response. Exposure of naïve mice to hapten also induced an increase in the proportion of migratory Tregs, demonstrating that innate signals can also induce Treg migration. Simultaneous examination of the migration of CD4+ effector cells and Tregs in the same region of uninflamed skin demonstrated that effector cells behaved differently, being uniformly highly migratory. These findings indicate that Treg behavior in skin differs from that of CD4+ effector cells, in that only a low proportion of Tregs are migratory under resting conditions. However, during inflammation the proportion of migratory Tregs increases, raising the possibility that this response may be important in controlling skin inflammation." @default.
- W1509487799 created "2016-06-24" @default.
- W1509487799 creator A5009218688 @default.
- W1509487799 creator A5016350097 @default.
- W1509487799 creator A5040346731 @default.
- W1509487799 creator A5057689848 @default.
- W1509487799 date "2014-04-01" @default.
- W1509487799 modified "2023-09-28" @default.
- W1509487799 title "Dermal regulatory T cells display distinct migratory behavior that is modulated during adaptive and innate inflammation (650.13)" @default.
- W1509487799 cites W1486722793 @default.
- W1509487799 cites W1501511128 @default.
- W1509487799 cites W1510335744 @default.
- W1509487799 cites W1575585006 @default.
- W1509487799 cites W1982805461 @default.
- W1509487799 cites W1986646780 @default.
- W1509487799 cites W2000593679 @default.
- W1509487799 cites W2014540704 @default.
- W1509487799 cites W2021115043 @default.
- W1509487799 cites W2030378290 @default.
- W1509487799 cites W2068521142 @default.
- W1509487799 cites W2075870856 @default.
- W1509487799 cites W2076870975 @default.
- W1509487799 cites W2092894443 @default.
- W1509487799 cites W2094626486 @default.
- W1509487799 cites W2097863119 @default.
- W1509487799 cites W2101084939 @default.
- W1509487799 cites W2107111117 @default.
- W1509487799 cites W2113765099 @default.
- W1509487799 cites W2119100076 @default.
- W1509487799 cites W2130486201 @default.
- W1509487799 cites W2134362149 @default.
- W1509487799 cites W2144151756 @default.
- W1509487799 cites W2145420458 @default.
- W1509487799 cites W2151322257 @default.
- W1509487799 cites W2153979851 @default.
- W1509487799 cites W2155521069 @default.
- W1509487799 cites W2159610486 @default.
- W1509487799 cites W2166759276 @default.
- W1509487799 cites W2167377974 @default.
- W1509487799 cites W2171880654 @default.
- W1509487799 cites W2806760348 @default.
- W1509487799 doi "https://doi.org/10.1096/fasebj.28.1_supplement.650.13" @default.
- W1509487799 hasPublicationYear "2014" @default.
- W1509487799 type Work @default.
- W1509487799 sameAs 1509487799 @default.
- W1509487799 citedByCount "0" @default.
- W1509487799 crossrefType "journal-article" @default.
- W1509487799 hasAuthorship W1509487799A5009218688 @default.
- W1509487799 hasAuthorship W1509487799A5016350097 @default.
- W1509487799 hasAuthorship W1509487799A5040346731 @default.
- W1509487799 hasAuthorship W1509487799A5057689848 @default.
- W1509487799 hasConcept C136449434 @default.
- W1509487799 hasConcept C203014093 @default.
- W1509487799 hasConcept C2776090121 @default.
- W1509487799 hasConcept C2776914184 @default.
- W1509487799 hasConcept C2778296632 @default.
- W1509487799 hasConcept C2779675166 @default.
- W1509487799 hasConcept C2779727006 @default.
- W1509487799 hasConcept C47742525 @default.
- W1509487799 hasConcept C51785407 @default.
- W1509487799 hasConcept C79484868 @default.
- W1509487799 hasConcept C86803240 @default.
- W1509487799 hasConcept C8891405 @default.
- W1509487799 hasConcept C95444343 @default.
- W1509487799 hasConceptScore W1509487799C136449434 @default.
- W1509487799 hasConceptScore W1509487799C203014093 @default.
- W1509487799 hasConceptScore W1509487799C2776090121 @default.
- W1509487799 hasConceptScore W1509487799C2776914184 @default.
- W1509487799 hasConceptScore W1509487799C2778296632 @default.
- W1509487799 hasConceptScore W1509487799C2779675166 @default.
- W1509487799 hasConceptScore W1509487799C2779727006 @default.
- W1509487799 hasConceptScore W1509487799C47742525 @default.
- W1509487799 hasConceptScore W1509487799C51785407 @default.
- W1509487799 hasConceptScore W1509487799C79484868 @default.
- W1509487799 hasConceptScore W1509487799C86803240 @default.
- W1509487799 hasConceptScore W1509487799C8891405 @default.
- W1509487799 hasConceptScore W1509487799C95444343 @default.
- W1509487799 hasIssue "S1" @default.
- W1509487799 hasLocation W15094877991 @default.
- W1509487799 hasOpenAccess W1509487799 @default.
- W1509487799 hasPrimaryLocation W15094877991 @default.
- W1509487799 hasRelatedWork W1500755500 @default.
- W1509487799 hasRelatedWork W1509487799 @default.
- W1509487799 hasRelatedWork W1523292317 @default.
- W1509487799 hasRelatedWork W1893216485 @default.
- W1509487799 hasRelatedWork W1980694684 @default.
- W1509487799 hasRelatedWork W1997714882 @default.
- W1509487799 hasRelatedWork W2099473703 @default.
- W1509487799 hasRelatedWork W2943103324 @default.
- W1509487799 hasRelatedWork W3086443010 @default.
- W1509487799 hasRelatedWork W4290034612 @default.
- W1509487799 hasVolume "28" @default.
- W1509487799 isParatext "false" @default.
- W1509487799 isRetracted "false" @default.
- W1509487799 magId "1509487799" @default.
- W1509487799 workType "article" @default.