FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1509578301> ?p ?o ?g. }

• W1509578301 abstract "The serine/threonine kinase Akt, or protein kinase B, has recently been a focus of interest because of its activity to inhibit apoptosis. It mediates cell survival by acting as a transducer of signals from growth factor receptors that activate phosphatidylinositol 3-kinase. We analysed the expression of the isoforms Akt1 and Akt2 as well as phosphorylated Akt (pAkt) by immunohistochemistry in frozen tumour samples from 280 postmenopausal patients who participated in a randomised trial comparing cyclophosphamide–methotrexate–5-fluorouracil chemotherapy and postoperative radiotherapy. The patients were simultaneously randomised to tamoxifen or to no endocrine treatment. Marked staining was found in 24% of the tumours for Akt1, but in only 4% for Akt2. A low frequency of Akt2-positive cells (1–10%) was observed in another 26% of the tumours. pAkt was significantly associated with both Akt1 and Akt2 expression. Overexpression of erbB2 correlated significantly with pAkt (P = 0.0028). The benefit from tamoxifen was analysed in oestrogen receptor (ER)-positive patients. Patients with a negative status of Akt (no overexpression of Akt1, Akt2 or pAkt) showed significant benefit from tamoxifen. The relative rate of distant recurrence, with versus without tamoxifen, was 0.44 (95% confidence interval [CI], 0.25–0.79) for ER+/Akt1- patients, while it was 0.72 (95% CI, 0.34–1.53) for ER+/Akt1+ patients. The difference in rate ratio did not reach statistical significance. The rate of locoregional recurrence was significantly decreased with radiotherapy versus chemotherapy for Akt-negative patients (rate ratio, 0.23; 95% CI, 0.08–0.67; P = 0.0074), while no benefit was evident for the Akt-positive subgroup (rate ratio, 0.77; 95% CI, 0.31–1.9; P = 0.58). The interaction between Akt and the efficacy of radiotherapy was significant in multivariate analysis (P = 0.042). Activation of the Akt pathway is correlated with erbB2 overexpression in breast cancer. The results suggest that Akt may predict the local control benefit from radiotherapy." @default.
• W1509578301 created "2016-06-24" @default.
• W1509578301 creator A5002277818 @default.
• W1509578301 creator A5012452403 @default.
• W1509578301 creator A5020638129 @default.
• W1509578301 creator A5026065105 @default.
• W1509578301 creator A5044198521 @default.
• W1509578301 creator A5055189005 @default.
• W1509578301 creator A5089455549 @default.
• W1509578301 date "2003-04-01" @default.
• W1509578301 modified "2023-10-13" @default.
• W1509578301 title "Akt kinases in breast cancer and the results of adjuvant therapy" @default.
• W1509578301 cites W1539489658 @default.
• W1509578301 cites W1558515869 @default.
• W1509578301 cites W1562190372 @default.
• W1509578301 cites W1820219315 @default.
• W1509578301 cites W1834339553 @default.
• W1509578301 cites W1841309598 @default.
• W1509578301 cites W1954313480 @default.
• W1509578301 cites W1969443715 @default.
• W1509578301 cites W1970751001 @default.
• W1509578301 cites W1972083432 @default.
• W1509578301 cites W1979012323 @default.
• W1509578301 cites W1979909416 @default.
• W1509578301 cites W1984418041 @default.
• W1509578301 cites W1992506198 @default.
• W1509578301 cites W1997006452 @default.
• W1509578301 cites W1999466080 @default.
• W1509578301 cites W2000079492 @default.
• W1509578301 cites W2011402312 @default.
• W1509578301 cites W2015543753 @default.
• W1509578301 cites W2016706952 @default.
• W1509578301 cites W2022114529 @default.
• W1509578301 cites W2029882446 @default.
• W1509578301 cites W2030573603 @default.
• W1509578301 cites W2043395027 @default.
• W1509578301 cites W2048121649 @default.
• W1509578301 cites W2058720172 @default.
• W1509578301 cites W2059221693 @default.
• W1509578301 cites W2071763005 @default.
• W1509578301 cites W2073575984 @default.
• W1509578301 cites W2076953872 @default.
• W1509578301 cites W2080778537 @default.
• W1509578301 cites W2090551359 @default.
• W1509578301 cites W2092310663 @default.
• W1509578301 cites W2093888249 @default.
• W1509578301 cites W2097767970 @default.
• W1509578301 cites W2105496184 @default.
• W1509578301 cites W2105841693 @default.
• W1509578301 cites W2107131127 @default.
• W1509578301 cites W2125649123 @default.
• W1509578301 cites W2169260922 @default.
• W1509578301 cites W2170832900 @default.
• W1509578301 cites W2316576166 @default.
• W1509578301 cites W2411322203 @default.
• W1509578301 cites W2467229516 @default.
• W1509578301 cites W2921082412 @default.
• W1509578301 cites W4293241248 @default.
• W1509578301 doi "https://doi.org/10.1186/bcr569" @default.
• W1509578301 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/154147" @default.
• W1509578301 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12631397" @default.
• W1509578301 hasPublicationYear "2003" @default.
• W1509578301 type Work @default.
• W1509578301 sameAs 1509578301 @default.
• W1509578301 citedByCount "155" @default.
• W1509578301 countsByYear W15095783012012 @default.
• W1509578301 countsByYear W15095783012013 @default.
• W1509578301 countsByYear W15095783012014 @default.
• W1509578301 countsByYear W15095783012015 @default.
• W1509578301 countsByYear W15095783012016 @default.
• W1509578301 countsByYear W15095783012017 @default.
• W1509578301 countsByYear W15095783012018 @default.
• W1509578301 countsByYear W15095783012019 @default.
• W1509578301 countsByYear W15095783012020 @default.
• W1509578301 countsByYear W15095783012021 @default.
• W1509578301 countsByYear W15095783012022 @default.
• W1509578301 countsByYear W15095783012023 @default.
• W1509578301 crossrefType "journal-article" @default.
• W1509578301 hasAuthorship W1509578301A5002277818 @default.
• W1509578301 hasAuthorship W1509578301A5012452403 @default.
• W1509578301 hasAuthorship W1509578301A5020638129 @default.
• W1509578301 hasAuthorship W1509578301A5026065105 @default.
• W1509578301 hasAuthorship W1509578301A5044198521 @default.
• W1509578301 hasAuthorship W1509578301A5055189005 @default.
• W1509578301 hasAuthorship W1509578301A5089455549 @default.
• W1509578301 hasBestOaLocation W15095783011 @default.
• W1509578301 hasConcept C11960822 @default.
• W1509578301 hasConcept C121608353 @default.
• W1509578301 hasConcept C126322002 @default.
• W1509578301 hasConcept C143998085 @default.
• W1509578301 hasConcept C154137905 @default.
• W1509578301 hasConcept C2777176818 @default.
• W1509578301 hasConcept C502942594 @default.
• W1509578301 hasConcept C530470458 @default.
• W1509578301 hasConcept C55493867 @default.
• W1509578301 hasConcept C71924100 @default.
• W1509578301 hasConcept C75217442 @default.
• W1509578301 hasConcept C86803240 @default.
• W1509578301 hasConcept C88216763 @default.
• W1509578301 hasConceptScore W1509578301C11960822 @default.

• next