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- W150960273 abstract "Anthroponotic cutaneous leishmaniasis caused by Leishmania tropica has beenendemic in Aleppo, Syria for centuries. The first modem description of the diseasewas also done in Aleppo. A surveillance system is in place, and the numbers ofannual recorded cases have been rising from a few hundred to thousands in thelate 1980s, to more than 5,000 in most years from 1990, and to more than 10,000since 2003.A retrospective analysis of routinely collected demographic data wasperformed. The clinical course was examined in a subset of patients. One hundredand thirty-two patients were recruited for follow-up study. Parasites were isolatedfrom the lesions of these patients before treatment and during the course oftreatment. Eighty isolates were tested for drug sensitivity in amastigotemacrophagesystem and typed to species level. Molecular fingerprinting wasapplied to a subset of isolates. Interviews were held with patients or accompanyingadults about their knowledge, attitudes and practices regarding prevention,diagnosis and treatment.Leishmaniasis patients in Aleppo were younger than the general population(median age 13 vs. 19 years), and females predominated among adults. Childrenand males were more likely to have lesions on the face. Smear positivity decreasedwith patient age (OR=O.5 in over-forties compared to under-tens). Smear positivitypeaked at two-month lesion duration (OR=2.2 compared to lesion duration of<1 month). A significant proportion of patients, especially adults, did not completetheir treatment course.The isolated parasites were insensitive (median ECso=229 fig Sbv Iml) topentavalent antimony, the drug used in Aleppo, and to paromomycin but weresensitive to amphotericin B. No relationship was found between baseline parasitein vitro sensitivity and treatment duration. All the typed parasites were L. tropica.Parasite schizodemes clustered by place of isolation and by family." @default.
- W150960273 created "2016-06-24" @default.
- W150960273 creator A5029613270 @default.
- W150960273 date "2010-01-01" @default.
- W150960273 modified "2023-09-27" @default.
- W150960273 title "Treatment of localised cutaneous Leishmania tropica infection in Aleppo, Syria and drug sensitivity of clinical isolates" @default.
- W150960273 doi "https://doi.org/10.17037/pubs.01742275" @default.
- W150960273 hasPublicationYear "2010" @default.
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