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• W150960681 abstract "Cutaneous squamous cell carcinoma (SCC) is the second most common form of skin cancer in the United States. Using microarrays, we identified lower levels of microRNA-1 (miR-1) expression in skin from mice that are susceptible to chemicallyinduced skin cancer, compared to skin from resistant mice. Murine SCC cell lines show reduced levels of miR-1 compared to normal skin. We hypothesize that the decreased expression of miR-1 in susceptible mice and SCC cell lines suggests a possible role of miR-1 as a tumor suppressor in skin. To test our hypothesis, we transfected a miR-1 precursor into a murine SCC cell line, A5. Upon transfection, we measured decreased cell proliferation and migration, and increased apoptosis. Using in silico prediction programs, we identified Ets1 as a potential direct target of miR-1. We observed decreased Ets1 mRNA and protein expression in A5 cells transfected with miR-1. To determine if Ets1 is a direct target of miR-1, we cotransfected an Ets1 3’UTR luciferase construct and miR-1 into a normal keratinocyte cell line, C5N. We observed decreased luciferase expression at 24 hours posttransfection, suggesting that Ets1 is a direct target of miR-1. In conclusion, miR-1 appears to target Ets1 and act as a tumor suppressor by increasing apoptosis and decreasing proliferation and migration. In future studies, we will characterize the role of Ets1 in SCC cell proliferation, apoptosis, and migration, and identify other targets and tumor-related phenotypes associated with miR-1." @default.
• W150960681 created "2016-06-24" @default.
• W150960681 creator A5085521511 @default.
• W150960681 date "2011-06-01" @default.
• W150960681 modified "2023-09-27" @default.
• W150960681 title "Ets1 as a Target of MicroRNA-1 in Cutaneous Squamous Cell Carcinoma" @default.
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• W150960681 hasPublicationYear "2011" @default.
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