Matches in SemOpenAlex for { <https://semopenalex.org/work/W1509667718> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W1509667718 endingPage "109" @default.
- W1509667718 startingPage "97" @default.
- W1509667718 abstract "The purpose of the present study was to determine the effects of acetaldehyde on airway smooth muscle constriction and inflammation. An oral ethanol provocation test was performed in Japanese asthmatics to measure pulmonary function, blood ethanol, acetaldehyde and histamine. Acetaldehyde dehydrogenase 2 (ALDH2) genotype was determined by polymerase chain reaction (PCR) and ethanol patch test. Human bronchi and mast cells were stimulated with acetaldehyde in vitro. Mite allergen-sensitized mice were inoculated with intranasal acetaldehyde. Approximately half the asthmatic subjects developed bronchoconstriction with concomitant increases in blood acetaldehyde and histamine, which was associated with genetically reducedALDH2 activities. In vitro acetaldehyde stimulation induces bronchoconstriction and degranulation of human mast cells. It also induced granulocyte macrophage colony stimulating factor (GM-CSF) production and nuclear factor (NF)-kappaB activation in human bronchi and increased mite allergen-sensitized allergic inflammation in a murine model of asthma. We conclude that acetaldehyde has potential effects on human airway by two distinct mechanisms. As a metabolite of alcohol, its elevation following alcohol consumption induces airway mast cells to release histamine, which results in exacerbation of asthma in susceptible populations. And as an air pollutant contained in cigarette smoke, for example, its inhalation potentially increases airway inflammation." @default.
- W1509667718 created "2016-06-24" @default.
- W1509667718 creator A5003707084 @default.
- W1509667718 creator A5008944943 @default.
- W1509667718 creator A5024633867 @default.
- W1509667718 creator A5041567002 @default.
- W1509667718 creator A5086116258 @default.
- W1509667718 date "2006-04-20" @default.
- W1509667718 modified "2023-09-26" @default.
- W1509667718 title "Effects of Acetaldehyde on Human Airway Constriction and Inflammation" @default.
- W1509667718 doi "https://doi.org/10.1002/9780470511848.ch7" @default.
- W1509667718 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17590989" @default.
- W1509667718 hasPublicationYear "2006" @default.
- W1509667718 type Work @default.
- W1509667718 sameAs 1509667718 @default.
- W1509667718 citedByCount "10" @default.
- W1509667718 countsByYear W15096677182013 @default.
- W1509667718 countsByYear W15096677182014 @default.
- W1509667718 countsByYear W15096677182015 @default.
- W1509667718 countsByYear W15096677182018 @default.
- W1509667718 countsByYear W15096677182020 @default.
- W1509667718 crossrefType "other" @default.
- W1509667718 hasAuthorship W1509667718A5003707084 @default.
- W1509667718 hasAuthorship W1509667718A5008944943 @default.
- W1509667718 hasAuthorship W1509667718A5024633867 @default.
- W1509667718 hasAuthorship W1509667718A5041567002 @default.
- W1509667718 hasAuthorship W1509667718A5086116258 @default.
- W1509667718 hasConcept C1122143 @default.
- W1509667718 hasConcept C134018914 @default.
- W1509667718 hasConcept C170493617 @default.
- W1509667718 hasConcept C185592680 @default.
- W1509667718 hasConcept C203014093 @default.
- W1509667718 hasConcept C2776042228 @default.
- W1509667718 hasConcept C2776914184 @default.
- W1509667718 hasConcept C2776954882 @default.
- W1509667718 hasConcept C2777595113 @default.
- W1509667718 hasConcept C2780161600 @default.
- W1509667718 hasConcept C2780769369 @default.
- W1509667718 hasConcept C42219234 @default.
- W1509667718 hasConcept C49802076 @default.
- W1509667718 hasConcept C55493867 @default.
- W1509667718 hasConcept C71924100 @default.
- W1509667718 hasConcept C98274493 @default.
- W1509667718 hasConceptScore W1509667718C1122143 @default.
- W1509667718 hasConceptScore W1509667718C134018914 @default.
- W1509667718 hasConceptScore W1509667718C170493617 @default.
- W1509667718 hasConceptScore W1509667718C185592680 @default.
- W1509667718 hasConceptScore W1509667718C203014093 @default.
- W1509667718 hasConceptScore W1509667718C2776042228 @default.
- W1509667718 hasConceptScore W1509667718C2776914184 @default.
- W1509667718 hasConceptScore W1509667718C2776954882 @default.
- W1509667718 hasConceptScore W1509667718C2777595113 @default.
- W1509667718 hasConceptScore W1509667718C2780161600 @default.
- W1509667718 hasConceptScore W1509667718C2780769369 @default.
- W1509667718 hasConceptScore W1509667718C42219234 @default.
- W1509667718 hasConceptScore W1509667718C49802076 @default.
- W1509667718 hasConceptScore W1509667718C55493867 @default.
- W1509667718 hasConceptScore W1509667718C71924100 @default.
- W1509667718 hasConceptScore W1509667718C98274493 @default.
- W1509667718 hasLocation W15096677181 @default.
- W1509667718 hasLocation W15096677182 @default.
- W1509667718 hasOpenAccess W1509667718 @default.
- W1509667718 hasPrimaryLocation W15096677181 @default.
- W1509667718 hasRelatedWork W1810409014 @default.
- W1509667718 hasRelatedWork W1975703831 @default.
- W1509667718 hasRelatedWork W1987123587 @default.
- W1509667718 hasRelatedWork W2012378759 @default.
- W1509667718 hasRelatedWork W2068840900 @default.
- W1509667718 hasRelatedWork W2079465941 @default.
- W1509667718 hasRelatedWork W2080942817 @default.
- W1509667718 hasRelatedWork W2415865135 @default.
- W1509667718 hasRelatedWork W2748952813 @default.
- W1509667718 hasRelatedWork W2238707306 @default.
- W1509667718 isParatext "false" @default.
- W1509667718 isRetracted "false" @default.
- W1509667718 magId "1509667718" @default.
- W1509667718 workType "other" @default.