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- W1509674916 abstract "For years it was thought that cells under culture conditions were immortal; however, from the publication of the works of Leonard Hayflick, this concept changed. Hayflick demonstrated that somatic cells under culture conditions had a limited capacity to proliferate; they stop dividing and enter into permanent arrest in the cell cycle, known as senescence. A particular characteristic of this state is that the cell maintains its viability and metabolic activity, and despite the presence of nutrients and mitogens, it does not divide (Ouellette et al., 2000). There are reports of cells that have been maintained in this state during several decades (Michaloglou et al., 2005). Regarding the origin of this process in mammalian cells, two different and apparently contradictory hypotheses have been proposed: senescence as a mechanism that suppresses tumor development, and senescence as the loss of the cells’ regenerative capacity in vivo. In terms of the first hypothesis, senescence possesses a beneficial effect for the organism because it would avoid the development of cancer; otherwise, the second hypothesis would exert a harmful effect on organisms in that it would favor aging. Commentary will appear later on that both hypotheses joined together in the antagonist pleiotropic hypothesis (Williams, 1957; Campisi & Adda di Fagagna, 2007; Campisi, 2011)." @default.
- W1509674916 created "2016-06-24" @default.
- W1509674916 creator A5009466489 @default.
- W1509674916 creator A5040988514 @default.
- W1509674916 creator A5058112481 @default.
- W1509674916 date "2012-02-29" @default.
- W1509674916 modified "2023-09-27" @default.
- W1509674916 title "Cellular Senescence and Its Relation with Telomere" @default.
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