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- W1509679712 endingPage "127" @default.
- W1509679712 startingPage "81" @default.
- W1509679712 abstract "The aldol reaction is a powerful method for C-C bond formation. Enamine—iminium catalysis is the most developed, and it is nicely complimented by other modes of activation that rely on hydrogen bond formation. Mechanistically, all proline-based catalysts activate donors through the formation of an enamine intermediate. Other activation modes rely on enolate formation, ionic interactions, or hydrogen bond formation, though the mechanism is not always known. The organocatalytic direct approach gives access to enantiomerically pure/enriched syn- and anti-aldols bearing two stereogenic centers in high yields and with excellent stereoselectivity. There are some limitations: only a limited number of ketones and some enolizable aldehydes are workable nucleophiles in the direct aldol reaction, catalyst loading is often very high, and reaction times are long. Organocatalytic methodologies for the aldol reaction are among the simplest and most efficient thus discovered. This chapter also discusses Brønsted acid catalysts, and ketone-ketone reactions." @default.
- W1509679712 created "2016-06-24" @default.
- W1509679712 creator A5033871861 @default.
- W1509679712 creator A5065504856 @default.
- W1509679712 date "2013-05-10" @default.
- W1509679712 modified "2023-09-26" @default.
- W1509679712 title "C-C Bond Formation by Aldol Reaction" @default.
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