FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1509912507> ?p ?o ?g. }

• W1509912507 endingPage "521" @default.
• W1509912507 startingPage "516" @default.
• W1509912507 abstract "The myxoma and malignant rabbit fibroma poxviruses are lethal tumorigenic viruses of rabbits whose virulence is modulated by the production of a virus-encoded secreted serine proteinase inhibitor, SERP-1. This viral protein was detected in medium harvested from myxoma and malignant rabbit fibroma virus-infected cells, and its inhibitory profile has been characterized by gel and kinetic analysis. SERP-1 forms complexes with and inhibits the human fibrinolytic enzymes plasmin, urokinase, and two-chain tissue-type plasminogen activator (association rate constants 3.4 x 10(4), 4.3 x 10(4), and 3.6 x 10(4) M-1 s-1 respectively). It is also able to inhibit C1S, the first enzyme in the complement cascade with an association rate constant which was unaffected by the addition of heparin (1.3 x 10(3) M-1 s-1). SERP-1 acts as a substrate for and is cleaved by thrombin, porcine trypsin, human neutrophil elastase, porcine pancreatic elastase, thermolysin, subtilisin, bovine alpha-chymotrypsin, and factor Xa. Incubation with kallikrein and cathepsin G had no effect. The structure of SERP-1 has been modeled on other members of the serpin family which revealed the characteristic serpin architecture apart from the absence of the D-helix. Structural analysis and kinetic assays demonstrate that the absence of this region does not prevent inhibitory activity and furthermore allow the identification of cysteine residues involved in internal and intermolecular disulfide bonding." @default.
• W1509912507 created "2016-06-24" @default.
• W1509912507 creator A5005679926 @default.
• W1509912507 creator A5033180528 @default.
• W1509912507 creator A5036734448 @default.
• W1509912507 creator A5040591138 @default.
• W1509912507 creator A5065736770 @default.
• W1509912507 date "1993-01-01" @default.
• W1509912507 modified "2023-10-18" @default.
• W1509912507 title "Inhibition of plasmin, urokinase, tissue plasminogen activator, and C1S by a myxoma virus serine proteinase inhibitor." @default.
• W1509912507 cites W1519781060 @default.
• W1509912507 cites W1522561094 @default.
• W1509912507 cites W1543429526 @default.
• W1509912507 cites W1563535758 @default.
• W1509912507 cites W1592886905 @default.
• W1509912507 cites W1634475175 @default.
• W1509912507 cites W1758269067 @default.
• W1509912507 cites W184609806 @default.
• W1509912507 cites W1909674996 @default.
• W1509912507 cites W1963947548 @default.
• W1509912507 cites W1973516851 @default.
• W1509912507 cites W1977244362 @default.
• W1509912507 cites W1985469117 @default.
• W1509912507 cites W2006876120 @default.
• W1509912507 cites W2008197854 @default.
• W1509912507 cites W2017708875 @default.
• W1509912507 cites W2026185422 @default.
• W1509912507 cites W2027739998 @default.
• W1509912507 cites W2036687837 @default.
• W1509912507 cites W2041065606 @default.
• W1509912507 cites W2043330027 @default.
• W1509912507 cites W2048986693 @default.
• W1509912507 cites W2049688582 @default.
• W1509912507 cites W2054722981 @default.
• W1509912507 cites W2057028899 @default.
• W1509912507 cites W2065707216 @default.
• W1509912507 cites W2073755494 @default.
• W1509912507 cites W2078119200 @default.
• W1509912507 cites W2100837269 @default.
• W1509912507 cites W2101108802 @default.
• W1509912507 cites W2107227531 @default.
• W1509912507 cites W2118551558 @default.
• W1509912507 cites W2138218584 @default.
• W1509912507 cites W2149026536 @default.
• W1509912507 cites W2152873608 @default.
• W1509912507 cites W2163021423 @default.
• W1509912507 cites W2170589157 @default.
• W1509912507 cites W2212388653 @default.
• W1509912507 cites W2397977594 @default.
• W1509912507 cites W330357786 @default.
• W1509912507 doi "https://doi.org/10.1016/s0021-9258(18)54181-8" @default.
• W1509912507 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8416956" @default.
• W1509912507 hasPublicationYear "1993" @default.
• W1509912507 type Work @default.
• W1509912507 sameAs 1509912507 @default.
• W1509912507 citedByCount "84" @default.
• W1509912507 countsByYear W15099125072014 @default.
• W1509912507 countsByYear W15099125072015 @default.
• W1509912507 countsByYear W15099125072016 @default.
• W1509912507 countsByYear W15099125072018 @default.
• W1509912507 countsByYear W15099125072020 @default.
• W1509912507 countsByYear W15099125072021 @default.
• W1509912507 countsByYear W15099125072022 @default.
• W1509912507 countsByYear W15099125072023 @default.
• W1509912507 crossrefType "journal-article" @default.
• W1509912507 hasAuthorship W1509912507A5005679926 @default.
• W1509912507 hasAuthorship W1509912507A5033180528 @default.
• W1509912507 hasAuthorship W1509912507A5036734448 @default.
• W1509912507 hasAuthorship W1509912507A5040591138 @default.
• W1509912507 hasAuthorship W1509912507A5065736770 @default.
• W1509912507 hasBestOaLocation W15099125071 @default.
• W1509912507 hasConcept C126322002 @default.
• W1509912507 hasConcept C134018914 @default.
• W1509912507 hasConcept C153911025 @default.
• W1509912507 hasConcept C159047783 @default.
• W1509912507 hasConcept C181199279 @default.
• W1509912507 hasConcept C185592680 @default.
• W1509912507 hasConcept C2522874641 @default.
• W1509912507 hasConcept C2776414213 @default.
• W1509912507 hasConcept C2776892390 @default.
• W1509912507 hasConcept C2779679481 @default.
• W1509912507 hasConcept C2779745803 @default.
• W1509912507 hasConcept C2781071845 @default.
• W1509912507 hasConcept C55493867 @default.
• W1509912507 hasConcept C71924100 @default.
• W1509912507 hasConcept C86803240 @default.
• W1509912507 hasConceptScore W1509912507C126322002 @default.
• W1509912507 hasConceptScore W1509912507C134018914 @default.
• W1509912507 hasConceptScore W1509912507C153911025 @default.
• W1509912507 hasConceptScore W1509912507C159047783 @default.
• W1509912507 hasConceptScore W1509912507C181199279 @default.
• W1509912507 hasConceptScore W1509912507C185592680 @default.
• W1509912507 hasConceptScore W1509912507C2522874641 @default.
• W1509912507 hasConceptScore W1509912507C2776414213 @default.
• W1509912507 hasConceptScore W1509912507C2776892390 @default.
• W1509912507 hasConceptScore W1509912507C2779679481 @default.
• W1509912507 hasConceptScore W1509912507C2779745803 @default.
• W1509912507 hasConceptScore W1509912507C2781071845 @default.

• next