Matches in SemOpenAlex for { <https://semopenalex.org/work/W1509967345> ?p ?o ?g. }
- W1509967345 endingPage "6407" @default.
- W1509967345 startingPage "6402" @default.
- W1509967345 abstract "The hydration of cis-epoxyeicosatrienoic acids to the corresponding vic-dihydroxyeicosatrienoic acids by cytosolic epoxide hydrolase demonstrates moderate regioselectivity with rates of hydration highest for the 14,15-epoxide and lower for the 11,12- and 8,9-epoxide (4.5, 1.6, and 1.5 mumol of product/mg of protein/min, respectively). Incubations of the 8,9- and 14,15-epoxides with cytosolic epoxide hydrolase show stereoselective formation of diols (7:3 and 4:1 ratio of antipodes, respectively) and concomitant chiral enrichment of the remaining unmetabolized substrate. In contrast, hydration of the 11,12-epoxide is nonenantioselective. The Km value of the enzyme for the 14(R),15(S)-epoxide is 3 microM. Incubations of the enantiomerically pure 8,9- and 14,15-epoxides with lung or liver cytosol, followed by chiral analysis of the resulting diols demonstrate selective cleavage of the oxirane ring at C9 and C15, respectively. On the other hand, cleavage of the 11,12- oxirane ring was less selective. The stereochemical preference of the cytosolic epoxide hydrolase, together with the known chiral composition of the endogenous arachidonate epoxide pools, suggests a functional role for this enzyme in the metabolism of these important compounds." @default.
- W1509967345 created "2016-06-24" @default.
- W1509967345 creator A5017429197 @default.
- W1509967345 creator A5020866795 @default.
- W1509967345 creator A5026538320 @default.
- W1509967345 creator A5041005296 @default.
- W1509967345 creator A5042587242 @default.
- W1509967345 creator A5075933490 @default.
- W1509967345 creator A5077198825 @default.
- W1509967345 date "1993-03-01" @default.
- W1509967345 modified "2023-10-01" @default.
- W1509967345 title "Regio- and enantiofacial selectivity of epoxyeicosatrienoic acid hydration by cytosolic epoxide hydrolase." @default.
- W1509967345 cites W1129365873 @default.
- W1509967345 cites W127854460 @default.
- W1509967345 cites W1483553420 @default.
- W1509967345 cites W1489520434 @default.
- W1509967345 cites W1495000055 @default.
- W1509967345 cites W1542098362 @default.
- W1509967345 cites W1547053328 @default.
- W1509967345 cites W1555774609 @default.
- W1509967345 cites W1571327998 @default.
- W1509967345 cites W1578135150 @default.
- W1509967345 cites W1607249944 @default.
- W1509967345 cites W1681118386 @default.
- W1509967345 cites W168132142 @default.
- W1509967345 cites W1966207709 @default.
- W1509967345 cites W1967242985 @default.
- W1509967345 cites W1968011115 @default.
- W1509967345 cites W1968130870 @default.
- W1509967345 cites W1970652710 @default.
- W1509967345 cites W1978229969 @default.
- W1509967345 cites W1980670563 @default.
- W1509967345 cites W1986227076 @default.
- W1509967345 cites W2000994563 @default.
- W1509967345 cites W2014542870 @default.
- W1509967345 cites W2019303947 @default.
- W1509967345 cites W2019360914 @default.
- W1509967345 cites W2023033845 @default.
- W1509967345 cites W2031657327 @default.
- W1509967345 cites W203186851 @default.
- W1509967345 cites W2032123123 @default.
- W1509967345 cites W2036538865 @default.
- W1509967345 cites W2040909870 @default.
- W1509967345 cites W2042357295 @default.
- W1509967345 cites W2043668307 @default.
- W1509967345 cites W2052711958 @default.
- W1509967345 cites W2054285094 @default.
- W1509967345 cites W2055186480 @default.
- W1509967345 cites W2060972092 @default.
- W1509967345 cites W2061608251 @default.
- W1509967345 cites W2068268829 @default.
- W1509967345 cites W2079808766 @default.
- W1509967345 cites W2081146243 @default.
- W1509967345 cites W2084646846 @default.
- W1509967345 cites W2091080408 @default.
- W1509967345 cites W2094975031 @default.
- W1509967345 cites W2102382467 @default.
- W1509967345 cites W2104200425 @default.
- W1509967345 cites W2107675352 @default.
- W1509967345 cites W2134408999 @default.
- W1509967345 cites W2162804035 @default.
- W1509967345 cites W2185536468 @default.
- W1509967345 cites W2206078611 @default.
- W1509967345 cites W3004973316 @default.
- W1509967345 cites W944320809 @default.
- W1509967345 cites W994481069 @default.
- W1509967345 doi "https://doi.org/10.1016/s0021-9258(18)53266-x" @default.
- W1509967345 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8454612" @default.
- W1509967345 hasPublicationYear "1993" @default.
- W1509967345 type Work @default.
- W1509967345 sameAs 1509967345 @default.
- W1509967345 citedByCount "200" @default.
- W1509967345 countsByYear W15099673452012 @default.
- W1509967345 countsByYear W15099673452013 @default.
- W1509967345 countsByYear W15099673452014 @default.
- W1509967345 countsByYear W15099673452015 @default.
- W1509967345 countsByYear W15099673452016 @default.
- W1509967345 countsByYear W15099673452017 @default.
- W1509967345 countsByYear W15099673452018 @default.
- W1509967345 countsByYear W15099673452019 @default.
- W1509967345 countsByYear W15099673452020 @default.
- W1509967345 countsByYear W15099673452021 @default.
- W1509967345 countsByYear W15099673452022 @default.
- W1509967345 countsByYear W15099673452023 @default.
- W1509967345 crossrefType "journal-article" @default.
- W1509967345 hasAuthorship W1509967345A5017429197 @default.
- W1509967345 hasAuthorship W1509967345A5020866795 @default.
- W1509967345 hasAuthorship W1509967345A5026538320 @default.
- W1509967345 hasAuthorship W1509967345A5041005296 @default.
- W1509967345 hasAuthorship W1509967345A5042587242 @default.
- W1509967345 hasAuthorship W1509967345A5075933490 @default.
- W1509967345 hasAuthorship W1509967345A5077198825 @default.
- W1509967345 hasBestOaLocation W15099673451 @default.
- W1509967345 hasConcept C101819947 @default.
- W1509967345 hasConcept C118792377 @default.
- W1509967345 hasConcept C161790260 @default.
- W1509967345 hasConcept C181199279 @default.
- W1509967345 hasConcept C185592680 @default.