FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1510040584> ?p ?o ?g. }

• W1510040584 endingPage "1219" @default.
• W1510040584 startingPage "1209" @default.
• W1510040584 abstract "Abstract FoxO1, a member of the FoxO subfamily of forkhead transcription factors, is an important target for insulin and growth factor signaling in the regulation of metabolism, cell cycle and proliferation, and survival in peripheral tissues. However, its role in the central nervous system is mostly unknown. In this study, we examined the effect of neurotrophic factors on nuclear/cytoplasmic shuttling of FoxO1. We showed that insulin‐like growth factor‐1 (IGF‐1) and nerve growth factor (NGF) potently induced the nuclear exclusion of FoxO1‐green fluorescent protein (GFP) while neurotrophin (NT)‐3 and NT‐4 were much weaker and brain‐derived neurotrophic factor (BDNF) failed to induce FoxO1 translocation in PC12 cells. FoxO1 translocation was inhibited by LY294002, a well‐established PI3K/Akt kinase inhibitor. Moreover, FoxO1 was phosphorylated at Thr24 and Ser256 residues by the above neurotrophic factors, with the exception of BDNF. Triple mutant FoxO1, in which three Akt/PKB phosphorylation sites (Thr24, Ser256 and Ser319) were mutated to alanine, resulted in the complete nuclear targeting of the expressed FoxO1‐GFP fusion protein in the presence of the above neurotrophic factors in both PC12 cells and cultured hippocampal and cortical neurons. Taken together, these findings demonstrate that neurotrophic factors are able to regulate nuclear/cytoplasmic shuttling of FoxO1 via the PI3K/Akt pathway in neuronal cells." @default.
• W1510040584 created "2016-06-24" @default.
• W1510040584 creator A5014890363 @default.
• W1510040584 creator A5021836357 @default.
• W1510040584 creator A5038051369 @default.
• W1510040584 creator A5055183128 @default.
• W1510040584 creator A5061040765 @default.
• W1510040584 date "2005-04-26" @default.
• W1510040584 modified "2023-10-16" @default.
• W1510040584 title "Nuclear/cytoplasmic shuttling of the transcription factor FoxO1 is regulated by neurotrophic factors" @default.
• W1510040584 cites W1572909157 @default.
• W1510040584 cites W1625966995 @default.
• W1510040584 cites W1631908837 @default.
• W1510040584 cites W1970285990 @default.
• W1510040584 cites W1973222840 @default.
• W1510040584 cites W1973283904 @default.
• W1510040584 cites W1979012323 @default.
• W1510040584 cites W1986065867 @default.
• W1510040584 cites W198779817 @default.
• W1510040584 cites W2000440562 @default.
• W1510040584 cites W2001028187 @default.
• W1510040584 cites W2007530728 @default.
• W1510040584 cites W2012423618 @default.
• W1510040584 cites W2016356782 @default.
• W1510040584 cites W2020244870 @default.
• W1510040584 cites W2032989528 @default.
• W1510040584 cites W2034248726 @default.
• W1510040584 cites W2036837630 @default.
• W1510040584 cites W2037341437 @default.
• W1510040584 cites W2038436921 @default.
• W1510040584 cites W2038988941 @default.
• W1510040584 cites W2041771374 @default.
• W1510040584 cites W2044371812 @default.
• W1510040584 cites W2048493924 @default.
• W1510040584 cites W2049739654 @default.
• W1510040584 cites W2056388945 @default.
• W1510040584 cites W2060116181 @default.
• W1510040584 cites W2061617907 @default.
• W1510040584 cites W2062390485 @default.
• W1510040584 cites W2062629127 @default.
• W1510040584 cites W2064013576 @default.
• W1510040584 cites W2065678329 @default.
• W1510040584 cites W2065721749 @default.
• W1510040584 cites W2067799923 @default.
• W1510040584 cites W2070139659 @default.
• W1510040584 cites W2073611916 @default.
• W1510040584 cites W2076103389 @default.
• W1510040584 cites W2076262819 @default.
• W1510040584 cites W2079797384 @default.
• W1510040584 cites W2080198440 @default.
• W1510040584 cites W2081359005 @default.
• W1510040584 cites W2081450878 @default.
• W1510040584 cites W2084986953 @default.
• W1510040584 cites W2087197302 @default.
• W1510040584 cites W2087312926 @default.
• W1510040584 cites W2098563852 @default.
• W1510040584 cites W2102107479 @default.
• W1510040584 cites W2107664641 @default.
• W1510040584 cites W2108197605 @default.
• W1510040584 cites W2111470310 @default.
• W1510040584 cites W2117639173 @default.
• W1510040584 cites W2118813298 @default.
• W1510040584 cites W2124479860 @default.
• W1510040584 cites W2125403403 @default.
• W1510040584 cites W2125481927 @default.
• W1510040584 cites W2128960139 @default.
• W1510040584 cites W2133792873 @default.
• W1510040584 cites W2134678910 @default.
• W1510040584 cites W2137035181 @default.
• W1510040584 cites W2139565721 @default.
• W1510040584 cites W2149187994 @default.
• W1510040584 cites W2158916331 @default.
• W1510040584 cites W2164406482 @default.
• W1510040584 cites W2170513752 @default.
• W1510040584 cites W2400297448 @default.
• W1510040584 cites W4229704949 @default.
• W1510040584 cites W4231442978 @default.
• W1510040584 cites W4234908756 @default.
• W1510040584 cites W4237405922 @default.
• W1510040584 cites W4239718055 @default.
• W1510040584 cites W4240809199 @default.
• W1510040584 cites W4362060345 @default.
• W1510040584 doi "https://doi.org/10.1111/j.1471-4159.2005.03108.x" @default.
• W1510040584 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15934941" @default.
• W1510040584 hasPublicationYear "2005" @default.
• W1510040584 type Work @default.
• W1510040584 sameAs 1510040584 @default.
• W1510040584 citedByCount "46" @default.
• W1510040584 countsByYear W15100405842012 @default.
• W1510040584 countsByYear W15100405842013 @default.
• W1510040584 countsByYear W15100405842014 @default.
• W1510040584 countsByYear W15100405842015 @default.
• W1510040584 countsByYear W15100405842016 @default.
• W1510040584 countsByYear W15100405842017 @default.
• W1510040584 countsByYear W15100405842018 @default.
• W1510040584 countsByYear W15100405842019 @default.
• W1510040584 countsByYear W15100405842020 @default.
• W1510040584 countsByYear W15100405842021 @default.

• next