Matches in SemOpenAlex for { <https://semopenalex.org/work/W151004846> ?p ?o ?g. }
- W151004846 endingPage "298" @default.
- W151004846 startingPage "278" @default.
- W151004846 abstract "Although lupus is commonly thought of as a B-cell disease, evidence from murine models of lupus-like syndromes and our understanding of how T cells coordinate the overall immune response suggest that T cells play a fundamental role in this disorder. Our group has developed a model that directly implicates T cells in the initiation of drug-induced and idiopathic lupus, and suggests molecular mechanisms relevant to this process. These studies derive from experiments aimed at determining the importance of DNA methylation in the regulation of T-cell function and gene expression. One particularly interesting outcome of these experiments is that hypomethylated CD4+ cells are no longer dependent on antigen for activation, and respond to antigen-presenting cells (APCs) lacking specific antigen, thus demonstrating characteristics of autoreactivity. We have used this observation to develop a working model for the study of both idiopathic and drug-induced lupus, in which methylation changes in the promoter sequences of critical genes lead to autoreactivity, and the autoreactive T cells then induce an autoimmune disease. This chapter reviews the current concepts regarding DNA methylation and its role in gene regulation, and relates this information to our model of T-cell—induced lupus-like disease. Finally, this chapter describes our current work for consideration as an area of research to be pursued to understand fully the molecular events initiating lupus." @default.
- W151004846 created "2016-06-24" @default.
- W151004846 creator A5030199082 @default.
- W151004846 creator A5080494386 @default.
- W151004846 date "1999-01-01" @default.
- W151004846 modified "2023-09-23" @default.
- W151004846 title "Impaired DNA Methylation in Lupus T Cells" @default.
- W151004846 cites W1517829477 @default.
- W151004846 cites W1537631996 @default.
- W151004846 cites W1544893850 @default.
- W151004846 cites W1548506428 @default.
- W151004846 cites W1550039558 @default.
- W151004846 cites W1562973495 @default.
- W151004846 cites W1571382825 @default.
- W151004846 cites W1576611598 @default.
- W151004846 cites W1618453919 @default.
- W151004846 cites W167981432 @default.
- W151004846 cites W1817131636 @default.
- W151004846 cites W1823692109 @default.
- W151004846 cites W1865658459 @default.
- W151004846 cites W1866576804 @default.
- W151004846 cites W1884280719 @default.
- W151004846 cites W1963817994 @default.
- W151004846 cites W1965742429 @default.
- W151004846 cites W1966286149 @default.
- W151004846 cites W1968913698 @default.
- W151004846 cites W1969373767 @default.
- W151004846 cites W1975576726 @default.
- W151004846 cites W1978324852 @default.
- W151004846 cites W1982991963 @default.
- W151004846 cites W1983474825 @default.
- W151004846 cites W1986146295 @default.
- W151004846 cites W1987081708 @default.
- W151004846 cites W1987273695 @default.
- W151004846 cites W1994009027 @default.
- W151004846 cites W1998309975 @default.
- W151004846 cites W1998631235 @default.
- W151004846 cites W1999908168 @default.
- W151004846 cites W2003299672 @default.
- W151004846 cites W2008261028 @default.
- W151004846 cites W2010792988 @default.
- W151004846 cites W2012903967 @default.
- W151004846 cites W2014778085 @default.
- W151004846 cites W2014912378 @default.
- W151004846 cites W2020818573 @default.
- W151004846 cites W2026484360 @default.
- W151004846 cites W2027703149 @default.
- W151004846 cites W2029231027 @default.
- W151004846 cites W2033162367 @default.
- W151004846 cites W2035093315 @default.
- W151004846 cites W2035939797 @default.
- W151004846 cites W2036306565 @default.
- W151004846 cites W2036855155 @default.
- W151004846 cites W2037710811 @default.
- W151004846 cites W2041674913 @default.
- W151004846 cites W2044657120 @default.
- W151004846 cites W2046120554 @default.
- W151004846 cites W2046241907 @default.
- W151004846 cites W2049921896 @default.
- W151004846 cites W2049987819 @default.
- W151004846 cites W2050068478 @default.
- W151004846 cites W2055171335 @default.
- W151004846 cites W2058483881 @default.
- W151004846 cites W2058506354 @default.
- W151004846 cites W2065592762 @default.
- W151004846 cites W2066057376 @default.
- W151004846 cites W2078627116 @default.
- W151004846 cites W2080336014 @default.
- W151004846 cites W2083325443 @default.
- W151004846 cites W2084118479 @default.
- W151004846 cites W2085862124 @default.
- W151004846 cites W2090103702 @default.
- W151004846 cites W2090398385 @default.
- W151004846 cites W2091602444 @default.
- W151004846 cites W2097885269 @default.
- W151004846 cites W2098267746 @default.
- W151004846 cites W2098976753 @default.
- W151004846 cites W2100475900 @default.
- W151004846 cites W2102668737 @default.
- W151004846 cites W2113745107 @default.
- W151004846 cites W2114599216 @default.
- W151004846 cites W2117895482 @default.
- W151004846 cites W2122116522 @default.
- W151004846 cites W2123669297 @default.
- W151004846 cites W2127761554 @default.
- W151004846 cites W2128940002 @default.
- W151004846 cites W2134030720 @default.
- W151004846 cites W2134202806 @default.
- W151004846 cites W2135604208 @default.
- W151004846 cites W2137063551 @default.
- W151004846 cites W2139620481 @default.
- W151004846 cites W2143139324 @default.
- W151004846 cites W2145082129 @default.
- W151004846 cites W2145750252 @default.
- W151004846 cites W2152605676 @default.
- W151004846 cites W2157896232 @default.
- W151004846 cites W2165449027 @default.
- W151004846 cites W2165880713 @default.