FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1510057569> ?p ?o ?g. }

• W1510057569 endingPage "495" @default.
• W1510057569 startingPage "473" @default.
• W1510057569 abstract "Oncogenic mutations create cancer cells. Cancer cells require thrombin for growth, angiogenesis, and metastasis. All cancer patients display a hypercoagulable state, which includes platelet activation, blood coagulation, complement activation, vasodilatation, and inflammation. This often results in thrombosis, the second leading cause of death in cancer patients. It is established that chemically oversulfated glycosaminoglycans (GAGs) induce thrombin generation through contact system activation in human plasma. Thrombin is responsible for thrombosis. In this chapter, we show that plasmas from lung cancer patients contain activated contact systems apparent by the absence of high molecular weight kininogen and processed C1inh, by abnormal kallikrein and thrombin activities, and by increased glucosamine, galactosamine, and GAG levels. Activated contact systems were also evident in plasmas from breast, colon, and pancreatic cancer patients. These data suggest that GAGs or other molecules produced by tumors induce abnormal thrombin generation through contact system activation. Therefore, the contact system and glycans represent new targets for cancer diagnosis, prevention, and treatment." @default.
• W1510057569 created "2016-06-24" @default.
• W1510057569 creator A5006244789 @default.
• W1510057569 creator A5013532873 @default.
• W1510057569 creator A5021707712 @default.
• W1510057569 creator A5022944214 @default.
• W1510057569 creator A5050139902 @default.
• W1510057569 creator A5052167281 @default.
• W1510057569 creator A5078526337 @default.
• W1510057569 date "2010-01-01" @default.
• W1510057569 modified "2023-10-10" @default.
• W1510057569 title "Glycosaminoglycans and Activated Contact System in Cancer Patient Plasmas" @default.
• W1510057569 cites W1535201509 @default.
• W1510057569 cites W1981494425 @default.
• W1510057569 cites W1982913199 @default.
• W1510057569 cites W1983760732 @default.
• W1510057569 cites W1986214293 @default.
• W1510057569 cites W1986729016 @default.
• W1510057569 cites W1991143071 @default.
• W1510057569 cites W1996514632 @default.
• W1510057569 cites W2006279291 @default.
• W1510057569 cites W2014947083 @default.
• W1510057569 cites W2034365627 @default.
• W1510057569 cites W2041720304 @default.
• W1510057569 cites W2048430280 @default.
• W1510057569 cites W2057732760 @default.
• W1510057569 cites W2058252463 @default.
• W1510057569 cites W2061240200 @default.
• W1510057569 cites W2062127942 @default.
• W1510057569 cites W2063621230 @default.
• W1510057569 cites W2068773189 @default.
• W1510057569 cites W2069039049 @default.
• W1510057569 cites W2069700057 @default.
• W1510057569 cites W2069702330 @default.
• W1510057569 cites W2069944229 @default.
• W1510057569 cites W2073245859 @default.
• W1510057569 cites W2075780259 @default.
• W1510057569 cites W2075829402 @default.
• W1510057569 cites W2076249236 @default.
• W1510057569 cites W2078678101 @default.
• W1510057569 cites W2081848037 @default.
• W1510057569 cites W2097802875 @default.
• W1510057569 cites W2099073107 @default.
• W1510057569 cites W2103044015 @default.
• W1510057569 cites W2104514360 @default.
• W1510057569 cites W2111167373 @default.
• W1510057569 cites W2112956752 @default.
• W1510057569 cites W2114102727 @default.
• W1510057569 cites W2117507908 @default.
• W1510057569 cites W2119805230 @default.
• W1510057569 cites W2120680169 @default.
• W1510057569 cites W2123853803 @default.
• W1510057569 cites W2131813152 @default.
• W1510057569 cites W2147194771 @default.
• W1510057569 cites W2155066067 @default.
• W1510057569 cites W4211160326 @default.
• W1510057569 cites W4236362016 @default.
• W1510057569 cites W4246046385 @default.
• W1510057569 cites W4319425455 @default.
• W1510057569 doi "https://doi.org/10.1016/s1877-1173(10)93020-2" @default.
• W1510057569 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20807657" @default.
• W1510057569 hasPublicationYear "2010" @default.
• W1510057569 type Work @default.
• W1510057569 sameAs 1510057569 @default.
• W1510057569 citedByCount "21" @default.
• W1510057569 countsByYear W15100575692013 @default.
• W1510057569 countsByYear W15100575692015 @default.
• W1510057569 countsByYear W15100575692016 @default.
• W1510057569 countsByYear W15100575692018 @default.
• W1510057569 countsByYear W15100575692019 @default.
• W1510057569 countsByYear W15100575692022 @default.
• W1510057569 countsByYear W15100575692023 @default.
• W1510057569 crossrefType "book-chapter" @default.
• W1510057569 hasAuthorship W1510057569A5006244789 @default.
• W1510057569 hasAuthorship W1510057569A5013532873 @default.
• W1510057569 hasAuthorship W1510057569A5021707712 @default.
• W1510057569 hasAuthorship W1510057569A5022944214 @default.
• W1510057569 hasAuthorship W1510057569A5050139902 @default.
• W1510057569 hasAuthorship W1510057569A5052167281 @default.
• W1510057569 hasAuthorship W1510057569A5078526337 @default.
• W1510057569 hasConcept C121608353 @default.
• W1510057569 hasConcept C126322002 @default.
• W1510057569 hasConcept C181199279 @default.
• W1510057569 hasConcept C185592680 @default.
• W1510057569 hasConcept C203014093 @default.
• W1510057569 hasConcept C2776256026 @default.
• W1510057569 hasConcept C2777292125 @default.
• W1510057569 hasConcept C2777902427 @default.
• W1510057569 hasConcept C2778382381 @default.
• W1510057569 hasConcept C2780394083 @default.
• W1510057569 hasConcept C2781317560 @default.
• W1510057569 hasConcept C3018697912 @default.
• W1510057569 hasConcept C502942594 @default.
• W1510057569 hasConcept C52853521 @default.
• W1510057569 hasConcept C55493867 @default.
• W1510057569 hasConcept C71924100 @default.
• W1510057569 hasConcept C89560881 @default.
• W1510057569 hasConcept C96232424 @default.

• next