FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1510079413> ?p ?o ?g. }

• W1510079413 endingPage "4034" @default.
• W1510079413 startingPage "4025" @default.
• W1510079413 abstract "Vaccination that prevents tuberculosis (TB) disease, particularly in adolescents, would have the greatest impact on the global TB epidemic. Safety, reactogenicity and immunogenicity of the vaccine candidate M72/AS01E was evaluated in healthy, HIV-negative adolescents in a TB endemic region, regardless of Mycobacterium tuberculosis (M.tb) infection status.In a phase II, double-blind randomized, controlled study (NCT00950612), two doses of M72/AS01E or placebo were administered intramuscularly, one month apart. Participants were followed-up post-vaccination, for 6 months. M72-specific immunogenicity was evaluated by intracellular cytokine staining analysis of T cells and NK cells by flow cytometry.No serious adverse events were recorded. M72/AS01E induced robust T cell and antibody responses, including antigen-dependent NK cell IFN-γ production. CD4 and CD8 T cell responses were sustained at 6 months post vaccination. Irrespective of M.tb infection status, vaccination induced a high frequency of M72-specific CD4 T cells expressing multiple combinations of Th1 cytokines, and low level IL-17. We observed rapid boosting of immune responses in M.tb-infected participants, suggesting natural infection acts as a prime to vaccination.The clinically acceptable safety and immunogenicity profile of M72/AS01E in adolescents living in an area with high TB burden support the move to efficacy trials." @default.
• W1510079413 created "2016-06-24" @default.
• W1510079413 creator A5003891827 @default.
• W1510079413 creator A5004657536 @default.
• W1510079413 creator A5011882174 @default.
• W1510079413 creator A5015195207 @default.
• W1510079413 creator A5019029049 @default.
• W1510079413 creator A5030479970 @default.
• W1510079413 creator A5031165744 @default.
• W1510079413 creator A5033423842 @default.
• W1510079413 creator A5037284449 @default.
• W1510079413 creator A5038010070 @default.
• W1510079413 creator A5042151818 @default.
• W1510079413 creator A5055107421 @default.
• W1510079413 creator A5067846391 @default.
• W1510079413 creator A5083056084 @default.
• W1510079413 creator A5084998871 @default.
• W1510079413 creator A5089599654 @default.
• W1510079413 creator A5090240218 @default.
• W1510079413 date "2015-07-01" @default.
• W1510079413 modified "2023-10-15" @default.
• W1510079413 title "Safety and immunogenicity of candidate vaccine M72/AS01E in adolescents in a TB endemic setting" @default.
• W1510079413 cites W1534500133 @default.
• W1510079413 cites W1595107302 @default.
• W1510079413 cites W1652285615 @default.
• W1510079413 cites W1874438006 @default.
• W1510079413 cites W1976348617 @default.
• W1510079413 cites W1983042663 @default.
• W1510079413 cites W1996735753 @default.
• W1510079413 cites W2002319260 @default.
• W1510079413 cites W2007885803 @default.
• W1510079413 cites W2010318115 @default.
• W1510079413 cites W2027455101 @default.
• W1510079413 cites W2035201477 @default.
• W1510079413 cites W2038535814 @default.
• W1510079413 cites W2040780498 @default.
• W1510079413 cites W2048961513 @default.
• W1510079413 cites W2060352709 @default.
• W1510079413 cites W2065461284 @default.
• W1510079413 cites W2065791817 @default.
• W1510079413 cites W2066738380 @default.
• W1510079413 cites W2075477269 @default.
• W1510079413 cites W2081670280 @default.
• W1510079413 cites W2090008075 @default.
• W1510079413 cites W2100990607 @default.
• W1510079413 cites W2104122664 @default.
• W1510079413 cites W2105889293 @default.
• W1510079413 cites W2106682613 @default.
• W1510079413 cites W2107876252 @default.
• W1510079413 cites W2108696062 @default.
• W1510079413 cites W2111350904 @default.
• W1510079413 cites W2133539151 @default.
• W1510079413 cites W2136300807 @default.
• W1510079413 cites W2137285612 @default.
• W1510079413 cites W2137633461 @default.
• W1510079413 cites W2141047461 @default.
• W1510079413 cites W2149883005 @default.
• W1510079413 cites W2150645172 @default.
• W1510079413 cites W2150707766 @default.
• W1510079413 cites W2158035277 @default.
• W1510079413 cites W2158131183 @default.
• W1510079413 cites W2161842856 @default.
• W1510079413 cites W2165171138 @default.
• W1510079413 cites W2166696946 @default.
• W1510079413 doi "https://doi.org/10.1016/j.vaccine.2015.05.088" @default.
• W1510079413 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5845829" @default.
• W1510079413 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26072017" @default.
• W1510079413 hasPublicationYear "2015" @default.
• W1510079413 type Work @default.
• W1510079413 sameAs 1510079413 @default.
• W1510079413 citedByCount "97" @default.
• W1510079413 countsByYear W15100794132016 @default.
• W1510079413 countsByYear W15100794132017 @default.
• W1510079413 countsByYear W15100794132018 @default.
• W1510079413 countsByYear W15100794132019 @default.
• W1510079413 countsByYear W15100794132020 @default.
• W1510079413 countsByYear W15100794132021 @default.
• W1510079413 countsByYear W15100794132022 @default.
• W1510079413 countsByYear W15100794132023 @default.
• W1510079413 crossrefType "journal-article" @default.
• W1510079413 hasAuthorship W1510079413A5003891827 @default.
• W1510079413 hasAuthorship W1510079413A5004657536 @default.
• W1510079413 hasAuthorship W1510079413A5011882174 @default.
• W1510079413 hasAuthorship W1510079413A5015195207 @default.
• W1510079413 hasAuthorship W1510079413A5019029049 @default.
• W1510079413 hasAuthorship W1510079413A5030479970 @default.
• W1510079413 hasAuthorship W1510079413A5031165744 @default.
• W1510079413 hasAuthorship W1510079413A5033423842 @default.
• W1510079413 hasAuthorship W1510079413A5037284449 @default.
• W1510079413 hasAuthorship W1510079413A5038010070 @default.
• W1510079413 hasAuthorship W1510079413A5042151818 @default.
• W1510079413 hasAuthorship W1510079413A5055107421 @default.
• W1510079413 hasAuthorship W1510079413A5067846391 @default.
• W1510079413 hasAuthorship W1510079413A5083056084 @default.
• W1510079413 hasAuthorship W1510079413A5084998871 @default.
• W1510079413 hasAuthorship W1510079413A5089599654 @default.
• W1510079413 hasAuthorship W1510079413A5090240218 @default.
• W1510079413 hasBestOaLocation W15100794131 @default.

• next