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- W1510109728 abstract "Abstract 1. 1. Subcellular fractions of lactating-rabbit mammary glands have been characterised by the use of “marker” enzymes and these fractions were then examined for the presence of enzymes involved in fatty acid synthesis. 2. 2. Acetate: CoA ligase (EC 6.2.1.1) was found to be confined to the particle-free supernatant fraction, whereas acetyl-CoA carboxylase (EC 6.4.1.2) was distributed between the microsomal and the particle-free supernatant fractions. Fatty acid synthetase was almost entirely situated in the particle-free supernatant fraction. Much lower levels of acetyl-CoA carboxylase and no fatty acid synthetase were observed in the mitochondrial fraction. The implications of these findings are discussed. 3. 3. Acetyl-CoA carboxylase is the rate-limiting step in fatty acid synthesis in this tissue under the conditions used." @default.
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- W1510109728 date "1966-12-01" @default.
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- W1510109728 title "Fatty acid biosynthesis" @default.
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- W1510109728 doi "https://doi.org/10.1016/0005-2760(66)90033-6" @default.
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