FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1510134797> ?p ?o ?g. }

• W1510134797 endingPage "213" @default.
• W1510134797 startingPage "192" @default.
• W1510134797 abstract "In normal human subjects, when plasma insulin, glucagon and growth hormone were 'clamped' at basal concentrations (by infusion of somatostatin plus replacement infusion of these hormones), infusion of Intralipid and heparin increased plasma free fatty acid (FFA) concentrations to approx. 1.3 mM, and ketone body production increased 4-5 fold to approx. 11 mumol . kg -1 . min-1. Hyperglucagonaemia did not further increase ketogenesis. In conditions of combined insulin and glucagon deficiency (by infusion of somatostatin without insulin and glucagon), administration of Intralipid and heparin increased plasma FFA concentrations to approx. 2.2 mM but a further increase in ketone body production did not accompany this increase. In these conditions hyperglucagonaemia increased ketogenesis by 2-3 fold the increment seen in control studies. Infusion of adrenaline (epinephrine) in conditions in which insulin secretion was not inhibited caused only a transient increase in plasma FFA concentrations and in ketone body production. These data indicate: (1) that in humans increased FFA availability can markedly augment ketogenesis in the absence of insulin deficiency and without hyperglucagonaemia; (2) that glucagon can increase ketone body production during insulin deficiency but not in its absence; and (3) that insulin deficiency may be accompanied by increased ketogenesis only because of a lack of its restraint on lipolysis and because of the action of glucagon. Glucagon may be important in determining the magnitude of ketone body production for a given degree of FFA availability and insulin deficiency, and may be necessary for attainment of maximal rates of ketogenesis. Adrenaline increases ketone body production in humans, but whether this is primarily due to a direct effect on the liver or is mediated through enhancement of lipolysis remains to be determined." @default.
• W1510134797 created "2016-06-24" @default.
• W1510134797 creator A5016468114 @default.
• W1510134797 creator A5027183958 @default.
• W1510134797 creator A5088931891 @default.
• W1510134797 date "1982-01-01" @default.
• W1510134797 modified "2023-09-23" @default.
• W1510134797 title "Effects of Free Fatty Acids, Insulin, Glucagon and Adrenaline on Ketone Body Production in Humans" @default.
• W1510134797 cites W1499490708 @default.
• W1510134797 cites W1543862651 @default.
• W1510134797 cites W1600232156 @default.
• W1510134797 cites W1826779723 @default.
• W1510134797 cites W1953942880 @default.
• W1510134797 cites W1984224264 @default.
• W1510134797 cites W1984785775 @default.
• W1510134797 cites W1985756954 @default.
• W1510134797 cites W1989888046 @default.
• W1510134797 cites W2003781513 @default.
• W1510134797 cites W2005591907 @default.
• W1510134797 cites W2010301061 @default.
• W1510134797 cites W2010860185 @default.
• W1510134797 cites W2032441253 @default.
• W1510134797 cites W2041084070 @default.
• W1510134797 cites W2043047593 @default.
• W1510134797 cites W2052787384 @default.
• W1510134797 cites W2057934386 @default.
• W1510134797 cites W2066154192 @default.
• W1510134797 cites W2078073869 @default.
• W1510134797 cites W2079577855 @default.
• W1510134797 cites W2094616984 @default.
• W1510134797 cites W2102941122 @default.
• W1510134797 cites W2103557599 @default.
• W1510134797 cites W2111327129 @default.
• W1510134797 cites W2121016515 @default.
• W1510134797 cites W2133300575 @default.
• W1510134797 cites W2136112043 @default.
• W1510134797 cites W2138446078 @default.
• W1510134797 cites W2146314998 @default.
• W1510134797 cites W2154551468 @default.
• W1510134797 cites W2159685747 @default.
• W1510134797 cites W2165977408 @default.
• W1510134797 cites W2178164598 @default.
• W1510134797 cites W2182712924 @default.
• W1510134797 cites W2196957880 @default.
• W1510134797 cites W2278310395 @default.
• W1510134797 cites W2315969301 @default.
• W1510134797 cites W2328089478 @default.
• W1510134797 cites W2398052105 @default.
• W1510134797 cites W2768784070 @default.
• W1510134797 cites W62382645 @default.
• W1510134797 doi "https://doi.org/10.1002/9780470720691.ch11" @default.
• W1510134797 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7042239" @default.
• W1510134797 hasPublicationYear "1982" @default.
• W1510134797 type Work @default.
• W1510134797 sameAs 1510134797 @default.
• W1510134797 citedByCount "13" @default.
• W1510134797 crossrefType "other" @default.
• W1510134797 hasAuthorship W1510134797A5016468114 @default.
• W1510134797 hasAuthorship W1510134797A5027183958 @default.
• W1510134797 hasAuthorship W1510134797A5088931891 @default.
• W1510134797 hasConcept C126322002 @default.
• W1510134797 hasConcept C134018914 @default.
• W1510134797 hasConcept C140985366 @default.
• W1510134797 hasConcept C171089720 @default.
• W1510134797 hasConcept C185592680 @default.
• W1510134797 hasConcept C2776297358 @default.
• W1510134797 hasConcept C2777391703 @default.
• W1510134797 hasConcept C2778563252 @default.
• W1510134797 hasConcept C2779306644 @default.
• W1510134797 hasConcept C2780352109 @default.
• W1510134797 hasConcept C31532488 @default.
• W1510134797 hasConcept C62231903 @default.
• W1510134797 hasConcept C71315377 @default.
• W1510134797 hasConcept C71924100 @default.
• W1510134797 hasConcept C84693403 @default.
• W1510134797 hasConcept C86803240 @default.
• W1510134797 hasConceptScore W1510134797C126322002 @default.
• W1510134797 hasConceptScore W1510134797C134018914 @default.
• W1510134797 hasConceptScore W1510134797C140985366 @default.
• W1510134797 hasConceptScore W1510134797C171089720 @default.
• W1510134797 hasConceptScore W1510134797C185592680 @default.
• W1510134797 hasConceptScore W1510134797C2776297358 @default.
• W1510134797 hasConceptScore W1510134797C2777391703 @default.
• W1510134797 hasConceptScore W1510134797C2778563252 @default.
• W1510134797 hasConceptScore W1510134797C2779306644 @default.
• W1510134797 hasConceptScore W1510134797C2780352109 @default.
• W1510134797 hasConceptScore W1510134797C31532488 @default.
• W1510134797 hasConceptScore W1510134797C62231903 @default.
• W1510134797 hasConceptScore W1510134797C71315377 @default.
• W1510134797 hasConceptScore W1510134797C71924100 @default.
• W1510134797 hasConceptScore W1510134797C84693403 @default.
• W1510134797 hasConceptScore W1510134797C86803240 @default.
• W1510134797 hasLocation W15101347971 @default.
• W1510134797 hasLocation W15101347972 @default.
• W1510134797 hasOpenAccess W1510134797 @default.
• W1510134797 hasPrimaryLocation W15101347971 @default.
• W1510134797 hasRelatedWork W172161085 @default.
• W1510134797 hasRelatedWork W1980068317 @default.

• next