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• W1510213658 abstract "The production of recombinant human insulin consists of five main stages, accompanied by considerable transformation of molecules, concerning size, secondary structure and the presence of charged groups. The application of different methods, i.e., size-exclusion, ion-exchange and reversed-phase high-performance liquid chromatography (HPLC) and high-performance capillary electrophoresis (HPCE) (capillary zone electrophoresis and micellar electrokinetic capillary chromatography), to the analysis of insulin, insulin-related and non-insulin-related substances was studied. A combined HPLC-HPCE system for the step-by-step control of recombinant human insulin production technology is suggested. The advantages and shortcomings of these methods are discussed." @default.
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• W1510213658 date "1994-02-01" @default.
• W1510213658 modified "2023-09-27" @default.
• W1510213658 title "Recombinant human insulin" @default.
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• W1510213658 doi "https://doi.org/10.1016/0021-9673(94)85179-4" @default.
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