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- W1510234016 abstract "Abstract The substituent effects on the symptomatic and neurophysiological activities of a number of substituted benzyl (1R)-trans-chrysanthemates against American cockroaches were quantitatively analyzed using electronic, hydrophobic, and steric parameters. The effects were shown to be highly specific to substituent positions except for those on the neuroblocking activity. Steric effect of substituents represented by van der Waals volume was found to play the most significant role in determining the variation in each activity. Peculiar substituent effects depending upon the bulkiness and position of substituents, which had been observed in the toxicity of this class of compounds, can be rationalized by the present analysis indicating that the optimum van der Waals volume of substituents is largest at the ortho and smallest at the para position." @default.
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- W1510234016 date "1982-06-01" @default.
- W1510234016 modified "2023-10-07" @default.
- W1510234016 title "Quantitative structure-activity studies of substituted benzyl chrysanthemates" @default.
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- W1510234016 doi "https://doi.org/10.1016/0048-3575(82)90136-5" @default.
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