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• W1510283651 abstract "Article1 November 1959CLINICAL OBSERVATIONS REGARDING XANTHELASMAJOSEPH B. VACCA, M.D., WILLIAM A. KNIGHT JR., M.D., F.A.C.P., GORONWY O. BROUN SR., M.D., F.A.C.P.JOSEPH B. VACCA, M.D.Search for more papers by this author, WILLIAM A. KNIGHT JR., M.D., F.A.C.P.Search for more papers by this author, GORONWY O. BROUN SR., M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-51-5-1019 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptXanthelasma or xanthoma palpebrarum (figure 1) has been reported as being encountered more frequently than is any other type of cutaneous xanthoma.1 It has been noted to occur in many types of xanthomatosis, especially with xanthoma tuberosum and xanthoma disseminatum,1 but is believed not to occur with the xanthomatosis associated with essential hyperlipemia.2 It has been reported to occur in from 10 to 30% of the hypercholesterolemic members of families with familial hypercholesterolemic xanthomatosis,3, 4, 5, 6, 7, 8, 9 and in up to 80% of the members with xanthomatosis.2, 9, 10While a considerable number of reports are available...Bibliography1. Montgomery H: Cutaneous manifestations of diseases of lipid metabolism, M. Clin. North America 24: 1249, 1940. CrossrefGoogle Scholar2. LeverSmithHurley WPN: Idiopathic hyperlipemic and primary hypercholesterolemic xanthomatosis, J. Invest. Dermat. 22: 33, 1954. CrossrefMedlineGoogle Scholar3. Adlersberg D: Hypercholesterolemia with predisposition to atherosclerosis, Am. J. Med. 11: 600, 1951. CrossrefMedlineGoogle Scholar4. FliegelmanWilkinsonHand MCE: Genetics of xanthoma tuberosum multiplex, Arch. Dermat. and Syph. 58: 409, 1948. CrossrefGoogle Scholar5. Wilkinson C: Essential familial hypercholesterolemia; cutaneous, metabolic, and hereditary aspects, Bull. New York Acad. Med. 26: 670, 1950. MedlineGoogle Scholar6. WheelerSprague EH: The prevalence and significance of hypercholesterolemia among children and siblings of patients with hypercholesterolemic xanthomatosis, J. Clin. Investigation 32: 611, 1953. Google Scholar7. Wheler E: The genetic aspects of atherosclerosis, Am. J. Med. 23: 653, 1957. CrossrefMedlineGoogle Scholar8. Leonard J: Hereditary hypercholesterolemic xanthomatosis, Lancet 2: 1239, 1956. CrossrefGoogle Scholar9. PiperOrrild JL: Essential familial hypercholesterolemia and xanthomatosis, Am. J. Med. 21: 34, 1956. CrossrefMedlineGoogle Scholar10. MontgomeryOsterberg HA: Xanthomatosis. Correlation of clinical, histopathologic, and chemical studies of cutaneous xanthoma, Arch. Dermat. and Syph. 37: 373, 1938. CrossrefGoogle Scholar11. RigdonWilleford RG: Sudden death during childhood with xanthoma tuberosum, J. A. M. A. 142: 1268, 1950. CrossrefGoogle Scholar12. Svendsen M: Are supernormal cholesterol values in serum caused by a dominantly inherited factor? Acta med. Scandinav. 104: 235, 1940. CrossrefGoogle Scholar13. BoasParetsAdlersberg EAD: Hereditary disturbance of cholesterol metabolism: a factor in the genesis of atherosclerosis, Am. Heart J. 35: 611, 1948. CrossrefMedlineGoogle Scholar14. BoasAdlersberg ED: Familial hypercholesterolemia (xanthomatosis) and atherosclerosis, J. Mt. Sinai Hosp. 12: 84, 1945. Google Scholar15. AdlersbergParets DA: Genetics of atherosclerosis, J. A. M. A. 141: 246, 1949. CrossrefMedlineGoogle Scholar16. Muller C: Angina pectoris in hereditary xanthomatosis, Arch. Int. Med. 64: 675, 1939. CrossrefGoogle Scholar17. Alvard R: Coronary heart disease and xanthoma tuberosum associated with hereditary hyperlipemia, Arch. Int. Med. 84: 1002, 1949. CrossrefGoogle Scholar18. Montgomery HV: Cutaneous xanthomatosis, Ann. Int. Med. 13: 671, 1939-40. LinkGoogle Scholar19. Montgomery H, in Discussion, Epstein, N. N., Rosenman, R. H., and Gofman, J. W.: Serum lipoproteins and cholesterol metabolism in xanthelasma, Arch. Dermat. and Syph. 65: 70-81, 1952. CrossrefGoogle Scholar20. EpsteinRosenmanGofman NRJ: Serum lipoproteins and cholesterol metabolism in xanthelasma, Arch. Dermat. and Syph. 65: 70, 1952. CrossrefGoogle Scholar21. CurtisBerger AJ: Effect of feeding a lipotrophic substance to patients with xanthelasma, Arch. Dermat. and Syph. 52: 252, 1945. CrossrefGoogle Scholar22. SteinerDomanski AB: Serum cholesterol level in coronary arteriosclerosis, Arch. Int. Med. 71: 397, 1943. CrossrefGoogle Scholar23. BrownZlatkisZakBoyle HABA: Rapid procedure for determination of free serum cholesterol, Anal. Chem. 26: 397, 1954. CrossrefGoogle Scholar24. KunkelAhrensEisenmenger HEW: Application of turbidometric methods for estimation of gamma globulin and total lipids to the study of patients with liver disease, Gastroenterology 11: 499, 1948. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: St. Louis, Missouri*Received for publication March 2, 1959.From the Department of Internal Medicine, St. Louis University School of Medicine and Firmin Desloge Hospital, St. Louis, Missouri.Requests for reprints should be addressed to William A. Knight, Jr., M.D., Department of Internal Medicine, Firmin Desloge Hospital, 1325 South Grand Boulevard, St. Louis 4. Missouri. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByThe Face Is the Mirror of the Soul. The Cardiovascular Physical Exam Is Not Yet Dead!Risk of Non-Alcoholic Fatty Liver Disease in Xanthelasma PalpebrarumXanthelasma Palpebrarum: More than Meets the EyeXanthelasma Palpebrarum Artmış Nötrofil/Lenfosit ve Platelet/Lenfosit Oranı ile İlişkilidirVisible aging signs as risk markers for ischemic heart disease: Epidemiology, pathogenesis and clinical implicationsPLIEGUE DIAGONAL DEL LÓBULO AURICULAR (DE FRANK) Y SU RELACIÓN CON ENFERMEDAD CORONARIAXanthelasma palpebrarum and its relation to atherosclerotic risk factors and lipoprotein (a)Xanthelasma Palpebrarum-clinical and biochemical profile in a tertiary care hospital of DelhiLipid metabolism and apolipoprotein E phenotypes in patients with xanthelasmaThe pathogenesis and clinical significance of xanthelasma palpebrarumSerum lipids, lipoprotein lipids and coronary heart disease in patients with xanthelasma palpebrarumXanthelasma and hyperlipoproteinaemiaPresymptomatic Diagnosis of Ischæmic Heart DiseaseSerum lipid studies in familial hypercholesterolemic xanthomatosisExternal manifestations of internal diseaseMedical genetics 1959 1 November 1959Volume 51, Issue 5Page: 1019-1031KeywordsAttentionCholesterolHospital medicineMenopauseOverweightPatients Issue Published: 1 November 1959 PDF DownloadLoading ..." @default.
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