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- W1510325087 abstract "During meiotic prophase, DNA double-strand break (DSB) repair-mediated homologous recombination (HR) occurs for exchange of genetic information between homologous chromosomes. Unlike autosomes or female sex chromosomes, human male sex chromosomes X and Y share little homology. Although DSBs are generated throughout male sex chromosomes, homologous recombination does not occur for most regions and DSB repair process is significantly prolonged. As a result, male sex chromosomes are coated with many DNA damage response proteins and form a unique chromatin structure known as the XY body. Interestingly, associated with the prolonged DSB repair, transcription is repressed in the XY body but not in autosomes, a phenomenon known as meiotic sex chromosome inactivation (MSCI), which is critical for male meiosis. Here using mice as model organisms, we briefly summarize recent progress on DSB repair in meiotic prophase and focus on the mechanism and function of DNA damage response in the XY body." @default.
- W1510325087 created "2016-06-24" @default.
- W1510325087 creator A5001198088 @default.
- W1510325087 creator A5069046588 @default.
- W1510325087 date "2015-02-16" @default.
- W1510325087 modified "2023-10-12" @default.
- W1510325087 title "Double-strand break repair on sex chromosomes: challenges during male meiotic prophase" @default.
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- W1510325087 doi "https://doi.org/10.1080/15384101.2014.998070" @default.
- W1510325087 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4614871" @default.
- W1510325087 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25565522" @default.
- W1510325087 hasPublicationYear "2015" @default.
- W1510325087 type Work @default.