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- W1510343318 abstract "Bisphosphonates (BPs) are used most commonly in children with osteogenesis imperfecta, resulting in increased trabeculae and cortical thickness, increased bone density as measured by DXA (Dual Energy X-ray Absorptiometry), and improved vertebral morphology. Less well documented in controlled trials are decrease in long bone fractures, improved strength and motor function, and decreased pain. Outside of children with osteogenesis imperfecta, use of bisphosphonates in children is increasing, all of which is off-label. This is seen in children with other chronic conditions resulting in pediatric osteoporosis and insufficiency fractures. Additional indications include steroid dependency with progressive loss of bone density, avascular necrosis of bone, and chronic regional pain syndrome. This review highlights the potential benefits and risks of the use of bisphosphonates in these unique children at risk for fracture or bone collapse." @default.
- W1510343318 created "2016-06-24" @default.
- W1510343318 creator A5004992643 @default.
- W1510343318 date "2014-01-01" @default.
- W1510343318 modified "2023-10-05" @default.
- W1510343318 title "Bisphosphonate use in children with pediatric osteoporosis and other bone conditions" @default.
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- W1510343318 doi "https://doi.org/10.3233/prm-140281" @default.
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