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• W1510347472 abstract "Research Article1 January 1994free access Tyrosine phosphorylated p91 binds to a single element in the ISGF2/IRF-1 promoter to mediate induction by IFN alpha and IFN gamma, and is likely to autoregulate the p91 gene. R. Pine R. Pine Public Health Research Institute, New York, NY 10016. Search for more papers by this author A. Canova A. Canova Public Health Research Institute, New York, NY 10016. Search for more papers by this author C. Schindler C. Schindler Public Health Research Institute, New York, NY 10016. Search for more papers by this author R. Pine R. Pine Public Health Research Institute, New York, NY 10016. Search for more papers by this author A. Canova A. Canova Public Health Research Institute, New York, NY 10016. Search for more papers by this author C. Schindler C. Schindler Public Health Research Institute, New York, NY 10016. Search for more papers by this author Author Information R. Pine1, A. Canova1 and C. Schindler1 1Public Health Research Institute, New York, NY 10016. The EMBO Journal (1994)13:158-167https://doi.org/10.1002/j.1460-2075.1994.tb06245.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info ISGF2 was initially identified, purified and cloned as an interferon-alpha (IFN alpha) induced transcription factor that binds to the IFN-stimulated response element (ISRE) of IFN alpha/beta-stimulated genes (ISGs). It was reported to be transcriptionally regulated by several cytokines including IFN alpha and IFN gamma. IFN alpha and IFN gamma inducibility is mediated by a single element: a high affinity, nearly palindromic version of the IFN gamma activation site (GAS). The ISGF2 GAS is bound specifically by p91, which was previously identified as a subunit of the ISG activator ISGF3, and shown to mediate IFN gamma induction of the GBP gene via a GAS. Tyrosine phosphorylation and DNA binding activity of p91 parallel transcription of ISGF2 in response to IFN alpha and/or IFN gamma, consistent with induction mediated by only a GAS. Transcription of the genes that encode p91 and p113, another subunit of ISGF3, is activated only by IFN alpha. This result suggests induction mediated by an ISRE, and implies autoregulation, requiring the products of both genes. Specificity of the ISRE is the basis for the previous conclusion. In contrast, it appears likely that the ISGF2 GAS, and p91 or related factors, also mediate induction of ISGF2 by IL-6 and prolactin. Convergence of signalling pathways from at least four cytokines on this single site would thus be a key aspect of a general role for ISGF2 in cellular growth control. Previous ArticleNext Article Volume 13Issue 11 January 1994In this issue RelatedDetailsLoading ..." @default.
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• W1510347472 title "Tyrosine phosphorylated p91 binds to a single element in the ISGF2/IRF-1 promoter to mediate induction by IFN alpha and IFN gamma, and is likely to autoregulate the p91 gene." @default.
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• W1510347472 doi "https://doi.org/10.1002/j.1460-2075.1994.tb06245.x" @default.
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