Matches in SemOpenAlex for { <https://semopenalex.org/work/W1510361812> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W1510361812 abstract "Abstract : Breast cancer like all cancers, is a multi step process involving the sequential acquisition of genetic alterations over a period of time. Studying this process in humans is a prolonged and arduous task; therefore, animal models are a desirable alternative. We have used a Wntl transgenic mouse model to study the multiple genetic events in mammary cancer development. We infected these transgenic mice with the mouse mammary tumor virus (MMTV) to accelerate tumorigenesis and to molecularly tag proto-oncogenes that are activated in the resulting tumors and that cooperate with Wnt- 1 in mammary tumorigenesis. By examination of the tumors that lack activation of genes that are usual targets of MMTV insertions, we identified a common insertion locus for MMTV and determined the activated gene in this locus to be another member of the FGF family, Fgf8/8. Fgf8 is transcriptionaly activated in 50% of the tumors from infected Wntl transgenic mice in comparison to the lack of Fgf8 RNA in other tumors and mammary tissues, suggesting a strong oncogenic cooperation between Fgf8 and Wntl in mammary tumorigenesis. Fgf8 induced apoptosis of mammary epithelial cells as evidenced by nuclear condensation and fragmentation and oligonucleosomal laddering. Overexpression of the anti-apoptotic gene bcl2 in these cells transiently rescued or delayed the apoptosis induced by FGFs. These results describe a new property for FGFs and suggest that these growth factors play very important roles in regulating cell growth and death both in normal development as well as in pathological conditions like cancer." @default.
- W1510361812 created "2016-06-24" @default.
- W1510361812 creator A5062312921 @default.
- W1510361812 date "1995-09-01" @default.
- W1510361812 modified "2023-09-24" @default.
- W1510361812 title "Analysis of Multistep Mammary Tumorigenesis in WNT-1 Transgenic Mice." @default.
- W1510361812 cites W1496519404 @default.
- W1510361812 cites W1501542409 @default.
- W1510361812 cites W1751787271 @default.
- W1510361812 cites W1814546794 @default.
- W1510361812 cites W1922106993 @default.
- W1510361812 cites W1974883337 @default.
- W1510361812 cites W1983809085 @default.
- W1510361812 cites W1988365075 @default.
- W1510361812 cites W2033618020 @default.
- W1510361812 cites W2044117808 @default.
- W1510361812 cites W2059267677 @default.
- W1510361812 cites W2090968423 @default.
- W1510361812 cites W2100221815 @default.
- W1510361812 cites W2165781463 @default.
- W1510361812 cites W2444619274 @default.
- W1510361812 cites W83698905 @default.
- W1510361812 doi "https://doi.org/10.21236/ada302270" @default.
- W1510361812 hasPublicationYear "1995" @default.
- W1510361812 type Work @default.
- W1510361812 sameAs 1510361812 @default.
- W1510361812 citedByCount "0" @default.
- W1510361812 crossrefType "report" @default.
- W1510361812 hasAuthorship W1510361812A5062312921 @default.
- W1510361812 hasConcept C102230213 @default.
- W1510361812 hasConcept C104317684 @default.
- W1510361812 hasConcept C121608353 @default.
- W1510361812 hasConcept C137620995 @default.
- W1510361812 hasConcept C141035611 @default.
- W1510361812 hasConcept C190283241 @default.
- W1510361812 hasConcept C2776187077 @default.
- W1510361812 hasConcept C2778001805 @default.
- W1510361812 hasConcept C2778264664 @default.
- W1510361812 hasConcept C2779777497 @default.
- W1510361812 hasConcept C502942594 @default.
- W1510361812 hasConcept C530470458 @default.
- W1510361812 hasConcept C54355233 @default.
- W1510361812 hasConcept C555283112 @default.
- W1510361812 hasConcept C86803240 @default.
- W1510361812 hasConcept C95444343 @default.
- W1510361812 hasConceptScore W1510361812C102230213 @default.
- W1510361812 hasConceptScore W1510361812C104317684 @default.
- W1510361812 hasConceptScore W1510361812C121608353 @default.
- W1510361812 hasConceptScore W1510361812C137620995 @default.
- W1510361812 hasConceptScore W1510361812C141035611 @default.
- W1510361812 hasConceptScore W1510361812C190283241 @default.
- W1510361812 hasConceptScore W1510361812C2776187077 @default.
- W1510361812 hasConceptScore W1510361812C2778001805 @default.
- W1510361812 hasConceptScore W1510361812C2778264664 @default.
- W1510361812 hasConceptScore W1510361812C2779777497 @default.
- W1510361812 hasConceptScore W1510361812C502942594 @default.
- W1510361812 hasConceptScore W1510361812C530470458 @default.
- W1510361812 hasConceptScore W1510361812C54355233 @default.
- W1510361812 hasConceptScore W1510361812C555283112 @default.
- W1510361812 hasConceptScore W1510361812C86803240 @default.
- W1510361812 hasConceptScore W1510361812C95444343 @default.
- W1510361812 hasLocation W15103618121 @default.
- W1510361812 hasOpenAccess W1510361812 @default.
- W1510361812 hasPrimaryLocation W15103618121 @default.
- W1510361812 hasRelatedWork W1520852884 @default.
- W1510361812 hasRelatedWork W1603426668 @default.
- W1510361812 hasRelatedWork W1706221424 @default.
- W1510361812 hasRelatedWork W1733545086 @default.
- W1510361812 hasRelatedWork W1935043580 @default.
- W1510361812 hasRelatedWork W1992873952 @default.
- W1510361812 hasRelatedWork W1999054269 @default.
- W1510361812 hasRelatedWork W2034408892 @default.
- W1510361812 hasRelatedWork W2037455744 @default.
- W1510361812 hasRelatedWork W2041230100 @default.
- W1510361812 hasRelatedWork W2050786468 @default.
- W1510361812 hasRelatedWork W2051341133 @default.
- W1510361812 hasRelatedWork W2056818511 @default.
- W1510361812 hasRelatedWork W2104728809 @default.
- W1510361812 hasRelatedWork W2123312374 @default.
- W1510361812 hasRelatedWork W2129539814 @default.
- W1510361812 hasRelatedWork W2145299570 @default.
- W1510361812 hasRelatedWork W2554179067 @default.
- W1510361812 hasRelatedWork W322236600 @default.
- W1510361812 hasRelatedWork W9151476 @default.
- W1510361812 isParatext "false" @default.
- W1510361812 isRetracted "false" @default.
- W1510361812 magId "1510361812" @default.
- W1510361812 workType "report" @default.