Matches in SemOpenAlex for { <https://semopenalex.org/work/W1510455854> ?p ?o ?g. }
- W1510455854 endingPage "1110" @default.
- W1510455854 startingPage "1104" @default.
- W1510455854 abstract "Abstract Sepsis is associated with extensive complement activation, compromising innate immune defenses, especially in neutrophils (PMN). Recently, a second C5a receptor (C5L2) was detected on PMN without evidence of intracellular signaling. The current study was designed to determine changes in C5L2 in blood PMN during sepsis. In vitro exposure of PMN to C5a, but not to fMLP, led to reduced content of C5L2. Following cecal ligation and puncture-induced sepsis in rats, PMN demonstrated a time-dependent decrease in C5L2. In vivo blockade of C5a during experimental sepsis resulted in preservation of C5L2. Similarly, PMN from patients with progressive sepsis showed significantly reduced C5L2 expression (n = 26), which was virtually abolished in patients who developed multiorgan failure (n = 10). In contrast, sepsis survivors exhibited retention of C5L2 (n = 12/13). The data suggest that C5L2 on PMN diminishes during sepsis due to systemic generation of C5a, which is associated with a poor prognosis." @default.
- W1510455854 created "2016-06-24" @default.
- W1510455854 creator A5000051355 @default.
- W1510455854 creator A5013233663 @default.
- W1510455854 creator A5014295847 @default.
- W1510455854 creator A5023908387 @default.
- W1510455854 creator A5024003678 @default.
- W1510455854 creator A5033614646 @default.
- W1510455854 creator A5042966626 @default.
- W1510455854 creator A5043146312 @default.
- W1510455854 creator A5043890004 @default.
- W1510455854 creator A5048725428 @default.
- W1510455854 creator A5050363226 @default.
- W1510455854 creator A5054719216 @default.
- W1510455854 creator A5055002833 @default.
- W1510455854 creator A5060740658 @default.
- W1510455854 creator A5073481189 @default.
- W1510455854 creator A5085701512 @default.
- W1510455854 creator A5085780698 @default.
- W1510455854 date "2005-01-15" @default.
- W1510455854 modified "2023-09-28" @default.
- W1510455854 title "Changes in the Novel Orphan, C5a Receptor (C5L2), during Experimental Sepsis and Sepsis in Humans" @default.
- W1510455854 cites W1506539419 @default.
- W1510455854 cites W1527492294 @default.
- W1510455854 cites W1536303889 @default.
- W1510455854 cites W1543575007 @default.
- W1510455854 cites W1569271652 @default.
- W1510455854 cites W1590582894 @default.
- W1510455854 cites W1592616574 @default.
- W1510455854 cites W1895961787 @default.
- W1510455854 cites W1975107484 @default.
- W1510455854 cites W1975807362 @default.
- W1510455854 cites W1977905350 @default.
- W1510455854 cites W1983327604 @default.
- W1510455854 cites W1993346410 @default.
- W1510455854 cites W1993531307 @default.
- W1510455854 cites W1995525413 @default.
- W1510455854 cites W1995921067 @default.
- W1510455854 cites W1999617526 @default.
- W1510455854 cites W2008508773 @default.
- W1510455854 cites W2017973513 @default.
- W1510455854 cites W2019802642 @default.
- W1510455854 cites W2024875771 @default.
- W1510455854 cites W2029043948 @default.
- W1510455854 cites W2035433014 @default.
- W1510455854 cites W2052303540 @default.
- W1510455854 cites W2055585500 @default.
- W1510455854 cites W2059213607 @default.
- W1510455854 cites W2060831129 @default.
- W1510455854 cites W2060923435 @default.
- W1510455854 cites W2087203965 @default.
- W1510455854 cites W2088220499 @default.
- W1510455854 cites W2095464095 @default.
- W1510455854 cites W2099193072 @default.
- W1510455854 cites W2104982551 @default.
- W1510455854 cites W2123151246 @default.
- W1510455854 cites W2132317912 @default.
- W1510455854 cites W2132426657 @default.
- W1510455854 cites W2134862628 @default.
- W1510455854 cites W2139367421 @default.
- W1510455854 cites W2145577370 @default.
- W1510455854 cites W2155611113 @default.
- W1510455854 cites W2169295770 @default.
- W1510455854 cites W2768146862 @default.
- W1510455854 cites W4238585520 @default.
- W1510455854 cites W4239667529 @default.
- W1510455854 cites W4251894087 @default.
- W1510455854 doi "https://doi.org/10.4049/jimmunol.174.2.1104" @default.
- W1510455854 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15634936" @default.
- W1510455854 hasPublicationYear "2005" @default.
- W1510455854 type Work @default.
- W1510455854 sameAs 1510455854 @default.
- W1510455854 citedByCount "70" @default.
- W1510455854 countsByYear W15104558542012 @default.
- W1510455854 countsByYear W15104558542013 @default.
- W1510455854 countsByYear W15104558542014 @default.
- W1510455854 countsByYear W15104558542015 @default.
- W1510455854 countsByYear W15104558542016 @default.
- W1510455854 countsByYear W15104558542017 @default.
- W1510455854 countsByYear W15104558542018 @default.
- W1510455854 countsByYear W15104558542019 @default.
- W1510455854 countsByYear W15104558542020 @default.
- W1510455854 countsByYear W15104558542021 @default.
- W1510455854 countsByYear W15104558542022 @default.
- W1510455854 countsByYear W15104558542023 @default.
- W1510455854 crossrefType "journal-article" @default.
- W1510455854 hasAuthorship W1510455854A5000051355 @default.
- W1510455854 hasAuthorship W1510455854A5013233663 @default.
- W1510455854 hasAuthorship W1510455854A5014295847 @default.
- W1510455854 hasAuthorship W1510455854A5023908387 @default.
- W1510455854 hasAuthorship W1510455854A5024003678 @default.
- W1510455854 hasAuthorship W1510455854A5033614646 @default.
- W1510455854 hasAuthorship W1510455854A5042966626 @default.
- W1510455854 hasAuthorship W1510455854A5043146312 @default.
- W1510455854 hasAuthorship W1510455854A5043890004 @default.
- W1510455854 hasAuthorship W1510455854A5048725428 @default.
- W1510455854 hasAuthorship W1510455854A5050363226 @default.
- W1510455854 hasAuthorship W1510455854A5054719216 @default.