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- W1510602628 abstract "Aliment Pharmacol Ther 2011; 33: 194–202 Summary Background Andrographis paniculata is an herbal mixture used to treat inflammatory diseases. An extract of the herb, HMPL-004, inhibits TNF-α and IL-1β, and prevents colitis in animal models. Aim To determine the efficacy and safety of HMPL-004 in patients with mild-to-moderate ulcerative colitis. Methods A randomised, double-blind, multicentre, 8-week parallel group study was conducted using HMPL-004 1200 mg/day compared with 4500 mg/day of slow release mesalazine (mesalamine) granules in patients with mild-to-moderately active ulcerative colitis. Disease activity was assessed at baseline and every 2 weeks for clinical response, and at baseline and 8 weeks by colonoscopy. Results One hundred and twenty patients at five centres in China were randomised and dosed. Clinical remission and response were seen in 21% and 76% of HMPL-004-treated patients, and 16% and 82% of mesalazine-treated patients. By colonoscopy, remission and response were seen in 28% and 74% of HMPL-004-treated patients and 24% and 71% of mesalazine-treated patients, respectively. There was no significant difference between the two treatment groups. Conclusion HMPL-004 may be an efficacious alternative to mesalazine in ulcerative colitis." @default.
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- W1510602628 date "2010-11-30" @default.
- W1510602628 modified "2023-09-23" @default.
- W1510602628 title "Randomised clinical trial: herbal extract HMPL-004 in active ulcerative colitis - a double-blind comparison with sustained release mesalazine" @default.
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- W1510602628 doi "https://doi.org/10.1111/j.1365-2036.2010.04515.x" @default.
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