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• W1510632009 abstract "Abstract 13 C MRS was installed on a clinical scanner at 1.5 T in order to facilitate integrated MR examinations of human brain disorders. Using a simplified protocol, (1‐ 13 C) glucose and/or (1‐ 13 C) acetate were administered orally or by intravenous infusion. 13 C spectra of diagnostic quality were acquired in more than 100 consecutive studies. Novel 13 C neurochemical data contributed to the understanding of Alzheimer's, Canavan's, mitochondrial and hepatic encephalopathy, epilepsy and normal brain development. 13 C MRS uncovered hitherto unknown disorders of NAA‐synthesis, glutamate neurotransmission, TCA‐cycle and glycolysis. Despite low inherent signal‐to‐noise, natural abundance 13 C MRS showed diagnostic promise. 13 C MRS is feasible in a clinical setting, at reasonable cost in neonates, children, adults and elderly patients. Copyright © 2003 John Wiley & Sons, Ltd." @default.
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• W1510632009 date "2003-10-01" @default.
• W1510632009 modified "2023-10-14" @default.
• W1510632009 title "Clinical experience with ¹³C MRS <i>in vivo</i>" @default.
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• W1510632009 doi "https://doi.org/10.1002/nbm.852" @default.
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