FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1510646616> ?p ?o ?g. }

• W1510646616 abstract "Ovarian cancer is a deadly female reproductive cancer. Understanding the biological mechanisms underlying ovarian cancer could help lead to quicker and more accurate diagnosis and more effective treatments. Both changes in microRNA(miRNA) expression and miRNA/mRNA dysregulation have been associated with ovarian cancer. With the availability of whole-genome miRNA and mRNA sequencing we now have new potentials to study these associations. In this study, we performed a comprehensive analysis of miRNA and mRNA expression in ovarian cancer using an integrative network approach combined with association analysis. We developed an integrative approach to construct a network that illustrates the complex interplay among miRNA and gene expression from a systems perspective. Our method is composed of expanding networks from eQTL associations, building network associations in eQTL analysis, and then combine the networks into an integrated network. This integrated network takes account of miRNA expression quantitative trait loci (eQTL) associations, miRNAs and their targets, protein-protein interactions, co-expressions among miRNAs and genes respectively. Applied to the ovarian cancer data set from The Cancer Genome Atlas (TCGA), we created an integrated network with 167 nodes containing 108 miRNA-target interactions and 145 from protein-protein interactions, starting from 44 initial eQTLs. This integrated network encompassed 26 genes and 14 miRNAs associated with cancer. In particular, 11 genes and 12 miRNAs in the integrated network are associated with ovarian cancer. We demonstrated an integrated network approach that integrates multiple data sources at a systems level. We applied this approach to the TCGA ovarian cancer dataset, and constructed a network that provided a more inclusive view of miRNA and gene expression in ovarian cancer. This network included four separate types of interactions among miRNAs and genes. Simply analyzing each interaction component in isolation, such as the eQTL associations, the miRNA-target interactions or the protein-protein interactions, would create a much more limited network than the integrated one." @default.
• W1510646616 created "2016-06-24" @default.
• W1510646616 creator A5030822572 @default.
• W1510646616 creator A5055295290 @default.
• W1510646616 creator A5058260888 @default.
• W1510646616 creator A5063377969 @default.
• W1510646616 date "2015-03-18" @default.
• W1510646616 modified "2023-10-18" @default.
• W1510646616 title "An integrated network of microRNA and gene expression in ovarian cancer" @default.
• W1510646616 cites W1967434444 @default.
• W1510646616 cites W1971460830 @default.
• W1510646616 cites W1979450315 @default.
• W1510646616 cites W1992088789 @default.
• W1510646616 cites W2004306748 @default.
• W1510646616 cites W2005663602 @default.
• W1510646616 cites W2008323782 @default.
• W1510646616 cites W2014606320 @default.
• W1510646616 cites W2018838463 @default.
• W1510646616 cites W2024543108 @default.
• W1510646616 cites W2025943989 @default.
• W1510646616 cites W2033598166 @default.
• W1510646616 cites W2042060276 @default.
• W1510646616 cites W2047967134 @default.
• W1510646616 cites W2064895884 @default.
• W1510646616 cites W2065899119 @default.
• W1510646616 cites W2068976735 @default.
• W1510646616 cites W2069771703 @default.
• W1510646616 cites W2069974969 @default.
• W1510646616 cites W2072308607 @default.
• W1510646616 cites W2073151403 @default.
• W1510646616 cites W2073367400 @default.
• W1510646616 cites W2074693857 @default.
• W1510646616 cites W2081038787 @default.
• W1510646616 cites W2083381199 @default.
• W1510646616 cites W2084126321 @default.
• W1510646616 cites W2091576663 @default.
• W1510646616 cites W2097078077 @default.
• W1510646616 cites W2099258232 @default.
• W1510646616 cites W2099480878 @default.
• W1510646616 cites W2100697281 @default.
• W1510646616 cites W2103151642 @default.
• W1510646616 cites W2103413641 @default.
• W1510646616 cites W2104261859 @default.
• W1510646616 cites W2105924489 @default.
• W1510646616 cites W2108317100 @default.
• W1510646616 cites W2109227959 @default.
• W1510646616 cites W2110237047 @default.
• W1510646616 cites W2112686792 @default.
• W1510646616 cites W2112840798 @default.
• W1510646616 cites W2116738722 @default.
• W1510646616 cites W2122698311 @default.
• W1510646616 cites W2123696077 @default.
• W1510646616 cites W2125536613 @default.
• W1510646616 cites W2128768066 @default.
• W1510646616 cites W2130979840 @default.
• W1510646616 cites W2134679647 @default.
• W1510646616 cites W2137719587 @default.
• W1510646616 cites W2138152797 @default.
• W1510646616 cites W2142664116 @default.
• W1510646616 cites W2145632240 @default.
• W1510646616 cites W2153210075 @default.
• W1510646616 cites W2159675211 @default.
• W1510646616 cites W2160913143 @default.
• W1510646616 cites W2165764599 @default.
• W1510646616 cites W2169961966 @default.
• W1510646616 cites W2219978888 @default.
• W1510646616 cites W990924570 @default.
• W1510646616 doi "https://doi.org/10.1186/1471-2105-16-s5-s5" @default.
• W1510646616 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4402579" @default.
• W1510646616 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25860109" @default.
• W1510646616 hasPublicationYear "2015" @default.
• W1510646616 type Work @default.
• W1510646616 sameAs 1510646616 @default.
• W1510646616 citedByCount "24" @default.
• W1510646616 countsByYear W15106466162015 @default.
• W1510646616 countsByYear W15106466162016 @default.
• W1510646616 countsByYear W15106466162017 @default.
• W1510646616 countsByYear W15106466162018 @default.
• W1510646616 countsByYear W15106466162019 @default.
• W1510646616 countsByYear W15106466162020 @default.
• W1510646616 countsByYear W15106466162021 @default.
• W1510646616 crossrefType "journal-article" @default.
• W1510646616 hasAuthorship W1510646616A5030822572 @default.
• W1510646616 hasAuthorship W1510646616A5055295290 @default.
• W1510646616 hasAuthorship W1510646616A5058260888 @default.
• W1510646616 hasAuthorship W1510646616A5063377969 @default.
• W1510646616 hasBestOaLocation W15106466161 @default.
• W1510646616 hasConcept C104317684 @default.
• W1510646616 hasConcept C106208931 @default.
• W1510646616 hasConcept C121608353 @default.
• W1510646616 hasConcept C135763542 @default.
• W1510646616 hasConcept C145059251 @default.
• W1510646616 hasConcept C150194340 @default.
• W1510646616 hasConcept C153209595 @default.
• W1510646616 hasConcept C168393362 @default.
• W1510646616 hasConcept C2780427987 @default.
• W1510646616 hasConcept C54355233 @default.
• W1510646616 hasConcept C55105296 @default.
• W1510646616 hasConcept C60644358 @default.
• W1510646616 hasConcept C67339327 @default.

• next