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• W1510732832 abstract "Recent studies showed that 1,4‐dihydropyridine‐3,5‐dicarbamoyl derivatives with lipophilic groups have significant antitubercular activity. In this study, we have synthesized new derivatives of 1,4‐dihydropyridines bearing carbmethoxy and carbethoxy group at C‐3 and C‐5 of the 1,4‐dihydropyridine ring. In addition, 1 H ‐pyrazole ring is substituted at C‐4 position. These analogues were synthesized by multi‐component Hantzsch reaction. The in vitro antitubercular activity of compounds against Mycobacterium tuberculosis H 37 Rv was evaluated. The lowest minimum inhibitory concentration value, 0.02 μg/mL and SI > 500, was found for dimethyl 1,4‐dihydro‐4‐(3‐(4‐nitrophenyl)‐1‐phenyl‐1 H ‐pyrazol‐4‐yl)‐2,6‐dimethylpyridine‐3,5‐dicarboxylate 3f , diethyl 1,4‐dihydro‐4‐(3‐(4‐fluorophenyl)‐1‐phenyl‐1 H ‐pyrazol‐4‐yl)‐2,6‐dimethylpyridine‐3,5‐dicarbo‐xylate 4c and diethyl 1,4‐dihydro‐4‐(3‐(4‐bromophenyl)‐1‐phenyl‐1 H ‐pyrazol‐4‐yl)‐2,6‐dimethyl pyridine‐3,5‐dicarboxylate 4e, making them more potent than first‐line antitubercular drug isoniazid. In addition, these compounds exhibited relatively low cytotoxicity." @default.
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• W1510732832 date "2011-09-21" @default.
• W1510732832 modified "2023-10-16" @default.
• W1510732832 title "Synthesis and Biological Evaluation of Some Novel 1,4-Dihydropyridines as Potential AntiTubercular Agents" @default.
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• W1510732832 doi "https://doi.org/10.1111/j.1747-0285.2011.01233.x" @default.
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