FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1510791389> ?p ?o ?g. }

• W1510791389 endingPage "1125" @default.
• W1510791389 startingPage "1113" @default.
• W1510791389 abstract "The puberty- and fertility-regulating neuropeptide kisspeptin (KISS1) exerts dramatic effects on the physiology of adult gonadotrophin-releasing hormone (GnRH) neurones as a master regulator of mammalian reproduction. Given the action of KISS1 directly on adult GnRH neurones, and that KISS1 activates a signal transduction cascade involved in neurite growth in other neurones, we investigated whether KISS1 may play a role in the normal growth of GnRH neurites to the median eminence. A reverse transcription-polymerase chain reaction demonstrated the expression of Kiss1 mRNA in the embryonic mediobasal hypothalamus, the target region for GnRH neurite termination, as early as embryonic day 13.5 (E13.5), a time when the first GnRH neurites are arriving. Complementary expression of the mRNA encoding the KISS1 receptor, Kiss1r, in the preoptic area (POA) at E13.5 was also observed, suggesting that POA-resident GnRH neurones can respond to KISS1 from an early age. To examine the effects of KISS1 on GnRH neurite growth in isolation, E15.5 POA explants, containing GnRH neurones actively extending neurites, were grown in three-dimensional collagen gels. In the presence of KISS1 (1 μm), both the number and length of GnRH neurites were increased significantly compared to controls without KISS1. The effects of KISS1 on GnRH neurite growth could be inhibited by pretreatment with the phospholipase C inhibitor U73122 (50 μm), indicating that embryonic and adult GnRH neurones respond to KISS1 with the same intracellular signalling pathway. KISS1 provided in a concentration gradient from a fixed source had no effect on GnRH neurite growth, indicating that KISS1 does not function as a long-range chemoattractant. Taken together, these results identify KISS1 as a stimulator of GnRH neurite growth, and suggest that it influences GnRH neurites at close-range to innervate the median eminence. These data add a novel developmental role to the repertoire of the functions of KISS1 in mammalian reproduction." @default.
• W1510791389 created "2016-06-24" @default.
• W1510791389 creator A5007416964 @default.
• W1510791389 creator A5083994417 @default.
• W1510791389 date "2010-09-15" @default.
• W1510791389 modified "2023-10-16" @default.
• W1510791389 title "A Novel Developmental Role for Kisspeptin in the Growth of Gonadotrophin-Releasing Hormone Neurites to the Median Eminence in the Mouse" @default.
• W1510791389 cites W1571282894 @default.
• W1510791389 cites W1963483307 @default.
• W1510791389 cites W1963786892 @default.
• W1510791389 cites W1970574794 @default.
• W1510791389 cites W1972744301 @default.
• W1510791389 cites W1979274617 @default.
• W1510791389 cites W1982460275 @default.
• W1510791389 cites W1984905844 @default.
• W1510791389 cites W1991847642 @default.
• W1510791389 cites W1993928311 @default.
• W1510791389 cites W1993957466 @default.
• W1510791389 cites W1994991637 @default.
• W1510791389 cites W1998286971 @default.
• W1510791389 cites W2008343115 @default.
• W1510791389 cites W2010605441 @default.
• W1510791389 cites W2017356475 @default.
• W1510791389 cites W2023976238 @default.
• W1510791389 cites W2026998467 @default.
• W1510791389 cites W2028777780 @default.
• W1510791389 cites W2029618197 @default.
• W1510791389 cites W2032161027 @default.
• W1510791389 cites W2032320771 @default.
• W1510791389 cites W2035003360 @default.
• W1510791389 cites W2045824781 @default.
• W1510791389 cites W2047701792 @default.
• W1510791389 cites W2050595554 @default.
• W1510791389 cites W2053917977 @default.
• W1510791389 cites W2057463566 @default.
• W1510791389 cites W2059491678 @default.
• W1510791389 cites W2059597336 @default.
• W1510791389 cites W2060722431 @default.
• W1510791389 cites W2062591635 @default.
• W1510791389 cites W2067130406 @default.
• W1510791389 cites W2068426167 @default.
• W1510791389 cites W2071540424 @default.
• W1510791389 cites W2071810743 @default.
• W1510791389 cites W2073220855 @default.
• W1510791389 cites W2073305444 @default.
• W1510791389 cites W2075832981 @default.
• W1510791389 cites W2081351003 @default.
• W1510791389 cites W2083596595 @default.
• W1510791389 cites W2087438175 @default.
• W1510791389 cites W2090919464 @default.
• W1510791389 cites W2093793500 @default.
• W1510791389 cites W2096603652 @default.
• W1510791389 cites W2097955186 @default.
• W1510791389 cites W2103705551 @default.
• W1510791389 cites W2106279530 @default.
• W1510791389 cites W2109149134 @default.
• W1510791389 cites W2111824942 @default.
• W1510791389 cites W2120568375 @default.
• W1510791389 cites W2125128519 @default.
• W1510791389 cites W2127098199 @default.
• W1510791389 cites W2128871066 @default.
• W1510791389 cites W2136629665 @default.
• W1510791389 cites W2141115613 @default.
• W1510791389 cites W2142686356 @default.
• W1510791389 cites W2143506157 @default.
• W1510791389 cites W2148922923 @default.
• W1510791389 cites W2150454162 @default.
• W1510791389 cites W2150490881 @default.
• W1510791389 cites W2151918958 @default.
• W1510791389 cites W2152116408 @default.
• W1510791389 cites W2158795213 @default.
• W1510791389 cites W2165823177 @default.
• W1510791389 cites W2169931542 @default.
• W1510791389 cites W3022929715 @default.
• W1510791389 cites W3023672242 @default.
• W1510791389 doi "https://doi.org/10.1111/j.1365-2826.2010.02059.x" @default.
• W1510791389 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20722977" @default.
• W1510791389 hasPublicationYear "2010" @default.
• W1510791389 type Work @default.
• W1510791389 sameAs 1510791389 @default.
• W1510791389 citedByCount "35" @default.
• W1510791389 countsByYear W15107913892012 @default.
• W1510791389 countsByYear W15107913892013 @default.
• W1510791389 countsByYear W15107913892014 @default.
• W1510791389 countsByYear W15107913892015 @default.
• W1510791389 countsByYear W15107913892016 @default.
• W1510791389 countsByYear W15107913892017 @default.
• W1510791389 countsByYear W15107913892018 @default.
• W1510791389 countsByYear W15107913892021 @default.
• W1510791389 countsByYear W15107913892023 @default.
• W1510791389 crossrefType "journal-article" @default.
• W1510791389 hasAuthorship W1510791389A5007416964 @default.
• W1510791389 hasAuthorship W1510791389A5083994417 @default.
• W1510791389 hasConcept C113246987 @default.
• W1510791389 hasConcept C118303440 @default.
• W1510791389 hasConcept C126322002 @default.
• W1510791389 hasConcept C134018914 @default.
• W1510791389 hasConcept C170493617 @default.

• next