Matches in SemOpenAlex for { <https://semopenalex.org/work/W1510821895> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W1510821895 abstract "NELL2, a protein containing epidermal growth factor (EGF)-like repeats, is almost exclusively expressed in neurons, but the role it may play in neuronal function remains uncertain. We now show that NELL2 is selectively expressed in glutamatergic neurons throughout the brain, and that it enhances Ca/sup 2+/-dependent glutamate release and Ca/sup 2+/-activated vesicular exocytosis. Although NELL2 localizes mostly to the cytosol, it associates with the synaptic vesicle protein synaptophysin, excluding the SNARE protein synaptobrevin. A major glutamatergic function in the neuroendocrine brain is to enhance release of LHRH, the neurohormone controlling sexual development, at the time of puberty. In vivo disruption of NELL2 synthesis reduced LHRH release from the hypothalamus and delayed the initiation of puberty. These results identify NELL2 as a new component of glutamate exocytosis and provide evidence for its physiological involvement in a major, glutamatedependent process of neuroendocrine regulation." @default.
- W1510821895 created "2016-06-24" @default.
- W1510821895 creator A5026999837 @default.
- W1510821895 date "2005-12-22" @default.
- W1510821895 modified "2023-09-23" @default.
- W1510821895 title "Nell2 is a glutamatergic neuron-specific regulator for vesicular exocytosis" @default.
- W1510821895 cites W1593205516 @default.
- W1510821895 cites W1827674271 @default.
- W1510821895 cites W2023006665 @default.
- W1510821895 doi "https://doi.org/10.1109/korus.2004.1555770" @default.
- W1510821895 hasPublicationYear "2005" @default.
- W1510821895 type Work @default.
- W1510821895 sameAs 1510821895 @default.
- W1510821895 citedByCount "0" @default.
- W1510821895 crossrefType "proceedings-article" @default.
- W1510821895 hasAuthorship W1510821895A5026999837 @default.
- W1510821895 hasConcept C130316041 @default.
- W1510821895 hasConcept C134018914 @default.
- W1510821895 hasConcept C148785051 @default.
- W1510821895 hasConcept C169760540 @default.
- W1510821895 hasConcept C170493617 @default.
- W1510821895 hasConcept C175969161 @default.
- W1510821895 hasConcept C203014093 @default.
- W1510821895 hasConcept C204232928 @default.
- W1510821895 hasConcept C2776219046 @default.
- W1510821895 hasConcept C2777209535 @default.
- W1510821895 hasConcept C2780648746 @default.
- W1510821895 hasConcept C41625074 @default.
- W1510821895 hasConcept C49039625 @default.
- W1510821895 hasConcept C529278444 @default.
- W1510821895 hasConcept C55493867 @default.
- W1510821895 hasConcept C61174792 @default.
- W1510821895 hasConcept C86803240 @default.
- W1510821895 hasConcept C95444343 @default.
- W1510821895 hasConceptScore W1510821895C130316041 @default.
- W1510821895 hasConceptScore W1510821895C134018914 @default.
- W1510821895 hasConceptScore W1510821895C148785051 @default.
- W1510821895 hasConceptScore W1510821895C169760540 @default.
- W1510821895 hasConceptScore W1510821895C170493617 @default.
- W1510821895 hasConceptScore W1510821895C175969161 @default.
- W1510821895 hasConceptScore W1510821895C203014093 @default.
- W1510821895 hasConceptScore W1510821895C204232928 @default.
- W1510821895 hasConceptScore W1510821895C2776219046 @default.
- W1510821895 hasConceptScore W1510821895C2777209535 @default.
- W1510821895 hasConceptScore W1510821895C2780648746 @default.
- W1510821895 hasConceptScore W1510821895C41625074 @default.
- W1510821895 hasConceptScore W1510821895C49039625 @default.
- W1510821895 hasConceptScore W1510821895C529278444 @default.
- W1510821895 hasConceptScore W1510821895C55493867 @default.
- W1510821895 hasConceptScore W1510821895C61174792 @default.
- W1510821895 hasConceptScore W1510821895C86803240 @default.
- W1510821895 hasConceptScore W1510821895C95444343 @default.
- W1510821895 hasLocation W15108218951 @default.
- W1510821895 hasOpenAccess W1510821895 @default.
- W1510821895 hasPrimaryLocation W15108218951 @default.
- W1510821895 hasRelatedWork W1546762987 @default.
- W1510821895 hasRelatedWork W1964826832 @default.
- W1510821895 hasRelatedWork W1989721214 @default.
- W1510821895 hasRelatedWork W204911604 @default.
- W1510821895 hasRelatedWork W2054447098 @default.
- W1510821895 hasRelatedWork W2054785704 @default.
- W1510821895 hasRelatedWork W2063154294 @default.
- W1510821895 hasRelatedWork W2071529764 @default.
- W1510821895 hasRelatedWork W2085433160 @default.
- W1510821895 hasRelatedWork W2087351063 @default.
- W1510821895 hasRelatedWork W2115132771 @default.
- W1510821895 hasRelatedWork W2127040336 @default.
- W1510821895 hasRelatedWork W2176580488 @default.
- W1510821895 hasRelatedWork W2335872743 @default.
- W1510821895 hasRelatedWork W2342154891 @default.
- W1510821895 hasRelatedWork W2440302549 @default.
- W1510821895 hasRelatedWork W2527916473 @default.
- W1510821895 hasRelatedWork W2759348474 @default.
- W1510821895 hasRelatedWork W2918722435 @default.
- W1510821895 hasRelatedWork W54338062 @default.
- W1510821895 isParatext "false" @default.
- W1510821895 isRetracted "false" @default.
- W1510821895 magId "1510821895" @default.
- W1510821895 workType "article" @default.