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- W1510868754 abstract "Publisher Summary This chapter reviews the role that CXC chemokines play in mediating various events that are important and relevant to cancer. CXC chemokines can enhance innate and adaptive immunity, regulate angiogenesis, and mediate tumor‐cell metastases. The functions of CXC chemokines have a direct impact on both the biology of cancer and the host's response to the tumor. Tumor growth, invasion, and metastasis to distant organs are dependent on a highly orchestrated series of events including numerous steps: preneoplastic‐to‐neoplastic cellular transformation; the establishment of a proangiogenic environment; local tumor‐cell growth; separation from adjacent cells and/or extracellular matrix (ECM), followed by local invasion through ECM/vascular basement membrane and entry into the circulation; tumor‐cell embolization and extravasation; and metastatic tumor growth in distant organs based on Paget's theory of “seed and soil,” regarding the homing of tumor cells to a specific organ. The list of events that destine a tumor cell to invade and metastasize to distant organs in a specific manner is analogous to the process of leukocyte maturation, subsequent entry into the circulation, and eventual homing to specific tissue sites." @default.
- W1510868754 created "2016-06-24" @default.
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- W1510868754 date "2005-01-01" @default.
- W1510868754 modified "2023-10-13" @default.
- W1510868754 title "CXC Chemokines in Cancer" @default.
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