FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1510928501> ?p ?o ?g. }

• W1510928501 endingPage "1004" @default.
• W1510928501 startingPage "993" @default.
• W1510928501 abstract "Abstract Human clinical trials in type 1 diabetes (T1D) patients using mesenchymal stem cells (MSC) are presently underway without prior validation in a mouse model for the disease. In response to this void, we characterized bone marrow-derived murine MSC for their ability to modulate immune responses in the context of T1D, as represented in NOD mice. In comparison to NOD mice, BALB/c-MSC mice were found to express higher levels of the negative costimulatory molecule PD-L1 and to promote a shift toward Th2-like responses in treated NOD mice. In addition, transfer of MSC from resistant strains (i.e., nonobese resistant mice or BALB/c), but not from NOD mice, delayed the onset of diabetes when administered to prediabetic NOD mice. The number of BALB/c-MSC trafficking to the pancreatic lymph nodes of NOD mice was higher than in NOD mice provided autologous NOD-MSC. Administration of BALB/c-MSC temporarily resulted in reversal of hyperglycemia in 90% of NOD mice (p = 0.002). Transfer of autologous NOD-MSC imparted no such therapeutic benefit. We also noted soft tissue and visceral tumors in NOD-MSC-treated mice, which were uniquely observed in this setting (i.e., no tumors were present with BALB/c- or nonobese resistant mice-MSC transfer). The importance of this observation remains to be explored in humans, as inbred mice such as NOD may be more susceptible to tumor formation. These data provide important preclinical data supporting the basis for further development of allogeneic MSC-based therapies for T1D and, potentially, for other autoimmune disorders." @default.
• W1510928501 created "2016-06-24" @default.
• W1510928501 creator A5017804129 @default.
• W1510928501 creator A5019592349 @default.
• W1510928501 creator A5021645059 @default.
• W1510928501 creator A5023494315 @default.
• W1510928501 creator A5028007261 @default.
• W1510928501 creator A5028211848 @default.
• W1510928501 creator A5028314110 @default.
• W1510928501 creator A5030035838 @default.
• W1510928501 creator A5030128430 @default.
• W1510928501 creator A5035866336 @default.
• W1510928501 creator A5038605279 @default.
• W1510928501 creator A5057955366 @default.
• W1510928501 creator A5058975989 @default.
• W1510928501 creator A5060145442 @default.
• W1510928501 creator A5069049128 @default.
• W1510928501 creator A5071508075 @default.
• W1510928501 creator A5072006058 @default.
• W1510928501 date "2009-07-15" @default.
• W1510928501 modified "2023-10-16" @default.
• W1510928501 title "Immunomodulatory Function of Bone Marrow-Derived Mesenchymal Stem Cells in Experimental Autoimmune Type 1 Diabetes" @default.
• W1510928501 cites W1537104679 @default.
• W1510928501 cites W1910525326 @default.
• W1510928501 cites W1968255500 @default.
• W1510928501 cites W1969922518 @default.
• W1510928501 cites W1972171120 @default.
• W1510928501 cites W1972446428 @default.
• W1510928501 cites W1979043688 @default.
• W1510928501 cites W1981787940 @default.
• W1510928501 cites W1982408656 @default.
• W1510928501 cites W1984860462 @default.
• W1510928501 cites W1987081782 @default.
• W1510928501 cites W1988187199 @default.
• W1510928501 cites W2005982182 @default.
• W1510928501 cites W2014698810 @default.
• W1510928501 cites W2025690599 @default.
• W1510928501 cites W2033284503 @default.
• W1510928501 cites W2035040282 @default.
• W1510928501 cites W2035582618 @default.
• W1510928501 cites W2035976926 @default.
• W1510928501 cites W2044904982 @default.
• W1510928501 cites W2054248603 @default.
• W1510928501 cites W2054274983 @default.
• W1510928501 cites W2055670245 @default.
• W1510928501 cites W2056352055 @default.
• W1510928501 cites W2058109105 @default.
• W1510928501 cites W2076900766 @default.
• W1510928501 cites W2086367603 @default.
• W1510928501 cites W2089886696 @default.
• W1510928501 cites W2096428903 @default.
• W1510928501 cites W2105151699 @default.
• W1510928501 cites W2106117542 @default.
• W1510928501 cites W2113358240 @default.
• W1510928501 cites W211458602 @default.
• W1510928501 cites W2124680883 @default.
• W1510928501 cites W2124681817 @default.
• W1510928501 cites W2130882533 @default.
• W1510928501 cites W2131950300 @default.
• W1510928501 cites W2132160710 @default.
• W1510928501 cites W2134451319 @default.
• W1510928501 cites W2139973886 @default.
• W1510928501 cites W2143095313 @default.
• W1510928501 cites W2144337206 @default.
• W1510928501 cites W2153716166 @default.
• W1510928501 cites W2158840473 @default.
• W1510928501 cites W2159999899 @default.
• W1510928501 cites W2168662624 @default.
• W1510928501 cites W4248060226 @default.
• W1510928501 doi "https://doi.org/10.4049/jimmunol.0900803" @default.
• W1510928501 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3895445" @default.
• W1510928501 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19561093" @default.
• W1510928501 hasPublicationYear "2009" @default.
• W1510928501 type Work @default.
• W1510928501 sameAs 1510928501 @default.
• W1510928501 citedByCount "339" @default.
• W1510928501 countsByYear W15109285012012 @default.
• W1510928501 countsByYear W15109285012013 @default.
• W1510928501 countsByYear W15109285012014 @default.
• W1510928501 countsByYear W15109285012015 @default.
• W1510928501 countsByYear W15109285012016 @default.
• W1510928501 countsByYear W15109285012017 @default.
• W1510928501 countsByYear W15109285012018 @default.
• W1510928501 countsByYear W15109285012019 @default.
• W1510928501 countsByYear W15109285012020 @default.
• W1510928501 countsByYear W15109285012021 @default.
• W1510928501 countsByYear W15109285012022 @default.
• W1510928501 countsByYear W15109285012023 @default.
• W1510928501 crossrefType "journal-article" @default.
• W1510928501 hasAuthorship W1510928501A5017804129 @default.
• W1510928501 hasAuthorship W1510928501A5019592349 @default.
• W1510928501 hasAuthorship W1510928501A5021645059 @default.
• W1510928501 hasAuthorship W1510928501A5023494315 @default.
• W1510928501 hasAuthorship W1510928501A5028007261 @default.
• W1510928501 hasAuthorship W1510928501A5028211848 @default.
• W1510928501 hasAuthorship W1510928501A5028314110 @default.
• W1510928501 hasAuthorship W1510928501A5030035838 @default.
• W1510928501 hasAuthorship W1510928501A5030128430 @default.

• next