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- W151122302 abstract "Radioimmunoscintigraphy has become an important research tool following the successful production, characterization, and radiolabeling of murine monoclonal antibodies (Mab) [1–4]. Previous investigators have evaluated the clinical utility of radiolabeled monoclonal antibodies for diagnosing the metastatic spread of melanoma [5–8], prostatic cancer [9], colorectal cancer [10–13], and several other malignancies, as well as nonmalignant conditions such as acute myocardial infarction [14] and thromboembolic disorders [15], and for labeling blood cells [16]. At the University of Texas System Cancer Center, M.D. Anderson Hospital, we have studied immunoscintigraphy of melanoma with two different monoclonal antibodies labeled with indium-1ll (ZME-018 and 96.5), as well as in In-111-antiprostatic acid phosphatase Mab (PAY 276) for metastatic prostatic adenocarcinoma. These studies, as well as those of other workers, have been reviewed previously [17–19]. In this chapter we will review our experience in colorectal cancer immunoscintigraphy using In-111-labeled intact monoclonal antibody as well as F(ab’)2 fragments. We will first discuss advantages and/or disadvantages of the radio-labels used, including iodine-131, iodine-123, indium-1ll, and technetium-99m, followed by studies of other anti-colorectal antibodies and the antigens targeted. The Mabs to be discussed, both intact antibodies as well as their Fab and F(ab’)2 fragments, include anti-CEA, 17–1A, NS19–9, and B72.3." @default.
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- W151122302 date "1990-01-01" @default.
- W151122302 modified "2023-09-23" @default.
- W151122302 title "In-111 monoclonal antibody immunoscintigraphy of colorectal cancer" @default.
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- W151122302 doi "https://doi.org/10.1007/978-1-4613-1497-4_15" @default.
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