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- W1511253153 endingPage "CPath.S487" @default.
- W1511253153 startingPage "CPath.S487" @default.
- W1511253153 abstract "Tamoxifen is widely used for endocrine treatment and breast cancer prevention. It acts as both an estrogen antagonist in breast tissue and an estrogen agonist in the female lower genital tract. Tamoxifen causes severe gynecologic side effects, such as endometrial cancer. This review focuses on the effects of prolonged tamoxifen treatment on the human female genital tract and considers its tumorigenicity in the gynecologic organs through clinical data analysis. Tamoxifen is associated with an increased incidence of benign endometrial lesions such as polyps and hyperplasia and a two- to four-fold increased risk of endometrial cancer in postmenopausal patients. Moreover, the incidence of functional ovarian cysts is significantly high in premenopausal tamoxifen users. To prevent tamoxifen from having severe side effects in gynecologic organs, frequent gynecological examination should be performed for both premenopausal and postmenopausal patients with breast cancer who are treated with this drug." @default.
- W1511253153 created "2016-06-24" @default.
- W1511253153 creator A5021106027 @default.
- W1511253153 creator A5042898310 @default.
- W1511253153 creator A5059587982 @default.
- W1511253153 creator A5086185811 @default.
- W1511253153 date "2008-01-01" @default.
- W1511253153 modified "2023-10-16" @default.
- W1511253153 title "Tumorigenic Effects of Tamoxifen on the Female Genital Tract" @default.
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