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- W1511264993 abstract "The functioning of the adult mammalian cerebral cortex depends critically upon precise interconnections between specific thalamic nuclei and distinct cortical regions. Therefore, one central issue in understanding cortical development is determining the cellular and molecular strategies underlying the specification of thalamocortical projections. We address the role of axon–axon interactions and membrane-bound guidance molecules in the establishment of connections to and from the cortex. The results of these experiments suggest that the development of layer-specific patterns of afferent and efferent cortical connections does not depend upon neuronal activity. We present evidence that activity conveyed by thalamic afferents is required for the elaboration of the columnar specificity of cortical circuits." @default.
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- W1511264993 date "2007-09-28" @default.
- W1511264993 modified "2023-10-17" @default.
- W1511264993 title "The Specificity of Interactions Between the Cortex and the Thalamus" @default.
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- W1511264993 doi "https://doi.org/10.1002/9780470514795.ch9" @default.
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