Matches in SemOpenAlex for { <https://semopenalex.org/work/W1511339977> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W1511339977 abstract "1 Pretreatment doses of barbitone, pentobarbitone, ethanol, and phenytoin (diphenylhydantoin) in non-tolerant rats produced increases in operant responding at low doses and at higher doses resulted in decreases in responding.2 Daily barbitone injections (100 mg/kg, i.p.) resulted in the development of functional tolerance to both the stimulant and depressant effects of barbitone on responding.3 Barbitone tolerance development did not result in any change in the brain or plasma pharmacokinetics of barbitone.4 Barbitone-tolerant rats were cross-tolerant to the behavioural effects of pentobarbitone, ethanol, and phenytoin. The dose-effect curves for all of these drugs were shifted to the right in tolerant rats, compared to non-tolerant rats.5 Comparison of the brain and plasma levels of these drugs in non-tolerant and tolerant rats provided a means of separating functional cross-tolerance from dispositional cross-tolerance. Barbitone-tolerant rats appeared to be functionally cross-tolerant to ethanol in that there was no change in the brain and blood ethanol levels at times when the degree of behavioural impairment was substantially reduced. In contrast to ethanol, cross-tolerance to phenytoin appeared to be due to a decrease in the brain and plasma levels (dispositional tolerance). Cross-tolerance to pentobarbitone appeared to be comprised of both functional and dispositional cross-tolerance.6 The usefulness of a multidisciplinary approach in the analysis of sedative hypnotic tolerance and cross-tolerance is discussed. It is concluded that without the concurrent determination of both brain and plasma drug levels it would not be possible to distinguish between functional and dispositional tolerance." @default.
- W1511339977 created "2016-06-24" @default.
- W1511339977 creator A5001847538 @default.
- W1511339977 creator A5037701654 @default.
- W1511339977 creator A5073492320 @default.
- W1511339977 date "1979-02-01" @default.
- W1511339977 modified "2023-09-24" @default.
- W1511339977 title "BARBITONE-INDUCED TOLERANCE TO THE EFFECTS OF SEDATIVE-HYPNOTICS AND RELATED COMPOUNDS ON OPERANT BEHAVIOUR IN THE RAT" @default.
- W1511339977 cites W1015369671 @default.
- W1511339977 cites W1541013450 @default.
- W1511339977 cites W1927531734 @default.
- W1511339977 cites W1940656453 @default.
- W1511339977 cites W1961680966 @default.
- W1511339977 cites W2005018497 @default.
- W1511339977 cites W2026084522 @default.
- W1511339977 cites W2028243496 @default.
- W1511339977 cites W2030738162 @default.
- W1511339977 cites W2054085430 @default.
- W1511339977 cites W2066264664 @default.
- W1511339977 cites W2075227121 @default.
- W1511339977 cites W2076363230 @default.
- W1511339977 cites W2085981322 @default.
- W1511339977 cites W2207274518 @default.
- W1511339977 cites W2263719348 @default.
- W1511339977 cites W2266750219 @default.
- W1511339977 doi "https://doi.org/10.1111/j.1476-5381.1979.tb07817.x" @default.
- W1511339977 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1668609" @default.
- W1511339977 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/760896" @default.
- W1511339977 hasPublicationYear "1979" @default.
- W1511339977 type Work @default.
- W1511339977 sameAs 1511339977 @default.
- W1511339977 citedByCount "6" @default.
- W1511339977 crossrefType "journal-article" @default.
- W1511339977 hasAuthorship W1511339977A5001847538 @default.
- W1511339977 hasAuthorship W1511339977A5037701654 @default.
- W1511339977 hasAuthorship W1511339977A5073492320 @default.
- W1511339977 hasBestOaLocation W15113399772 @default.
- W1511339977 hasConcept C118552586 @default.
- W1511339977 hasConcept C185592680 @default.
- W1511339977 hasConcept C2776755955 @default.
- W1511339977 hasConcept C2777389121 @default.
- W1511339977 hasConcept C2777602617 @default.
- W1511339977 hasConcept C2778186239 @default.
- W1511339977 hasConcept C2778337148 @default.
- W1511339977 hasConcept C2779985140 @default.
- W1511339977 hasConcept C2780161600 @default.
- W1511339977 hasConcept C2780930544 @default.
- W1511339977 hasConcept C55493867 @default.
- W1511339977 hasConcept C71924100 @default.
- W1511339977 hasConcept C946728 @default.
- W1511339977 hasConcept C98274493 @default.
- W1511339977 hasConceptScore W1511339977C118552586 @default.
- W1511339977 hasConceptScore W1511339977C185592680 @default.
- W1511339977 hasConceptScore W1511339977C2776755955 @default.
- W1511339977 hasConceptScore W1511339977C2777389121 @default.
- W1511339977 hasConceptScore W1511339977C2777602617 @default.
- W1511339977 hasConceptScore W1511339977C2778186239 @default.
- W1511339977 hasConceptScore W1511339977C2778337148 @default.
- W1511339977 hasConceptScore W1511339977C2779985140 @default.
- W1511339977 hasConceptScore W1511339977C2780161600 @default.
- W1511339977 hasConceptScore W1511339977C2780930544 @default.
- W1511339977 hasConceptScore W1511339977C55493867 @default.
- W1511339977 hasConceptScore W1511339977C71924100 @default.
- W1511339977 hasConceptScore W1511339977C946728 @default.
- W1511339977 hasConceptScore W1511339977C98274493 @default.
- W1511339977 hasLocation W15113399771 @default.
- W1511339977 hasLocation W15113399772 @default.
- W1511339977 hasLocation W15113399773 @default.
- W1511339977 hasLocation W15113399774 @default.
- W1511339977 hasOpenAccess W1511339977 @default.
- W1511339977 hasPrimaryLocation W15113399771 @default.
- W1511339977 hasRelatedWork W1511339977 @default.
- W1511339977 hasRelatedWork W1965468598 @default.
- W1511339977 hasRelatedWork W1974573459 @default.
- W1511339977 hasRelatedWork W1999608526 @default.
- W1511339977 hasRelatedWork W2012248604 @default.
- W1511339977 hasRelatedWork W2020533417 @default.
- W1511339977 hasRelatedWork W2048247746 @default.
- W1511339977 hasRelatedWork W2126585192 @default.
- W1511339977 hasRelatedWork W2309118362 @default.
- W1511339977 hasRelatedWork W2440001328 @default.
- W1511339977 isParatext "false" @default.
- W1511339977 isRetracted "false" @default.
- W1511339977 magId "1511339977" @default.
- W1511339977 workType "article" @default.