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• W1511418459 startingPage "347" @default.
• W1511418459 abstract "Vasoactive intestinal peptide (VIP) is a neuroendocrine mediator in immune tissues that affects many T cell functions through two homologous high-affinity G-protein-coupled receptors, termed VIPR1 and VIPR2. Antigen-stimulated secretion of γ-interferon (IFN-γ) by sperm whale myoglobin-specific Th1 cells of DBA/2 mouse I-Ed-restricted clones, which express VIPR1 and VIPR2, was enhanced by 10−10 M to 10−7 M VIP. Enhancement of IFN-γ secretion reached a mean maximum of fourfold for VIP and threefold for a VIPR2-selective agonist, without any effect of a VIPR1-selective agonist. Secretion of IFN-γ by PMA and ionomycin-stimulated clones of Th1 cells was not altered by VIP. Antigen-stimulated secretion of IFN-γ by T cell receptor-transgenic, influenza hemagglutinin-specific, and cytokine-differentiated mouse lymph node Th1 cells, which also express VIPR1 and VIPR2, was enhanced by 10−10 M to 10−8 M VIP. Enhancement of IFN-γ secretion increased to a maximum of 14-fold for VIP, 14-fold for the VIPR2-selective agonist, and 20-fold for the VIPR1-selective agonist. In contrast to VIP suppression of interleukin production and lack of effect on IFN-γ production by T cells stimulated with anti-CD3 antibody or a mitogenic lectin, generation of IFN-γ by antigen-stimulated T cells is enhanced significantly by physiological concentrations of VIP.—Jabrane-Ferrat, N., Bloom, D., Wu, A., Li, L., Lo, D., Sreedharan, S. P., Turck, C. W., Goetzl, E. J. Enhancement by vasoactive intestinal peptide of γ-interferon production by antigen-stimulated type 1 helper T cells. FASEB J. 13, 347–353 (1999)" @default.
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• W1511418459 date "1999-02-01" @default.
• W1511418459 modified "2023-10-16" @default.
• W1511418459 title "Enhancement by vasoactive intestinal peptide of γ‐interferon production by antigen‐stimulated type 1 helper T cells" @default.
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• W1511418459 doi "https://doi.org/10.1096/fasebj.13.2.347" @default.
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